To stimulate research and evaluation on issues related to medication adherence, treatment persistence, and implications for health outcomes.


Medication non-adherence has a significant impact on patients’ morbidity and mortality. Behavioral interventions have been developed to improve medication adherence. Adherence research requires an understanding about the best methodology to conduct studies especially when assessing interventions. Adherence studies include various designs such as: randomized controlled clinical trials, observational, and quasi-experimental studies. The Medication Adherence and Persistence Special Interest Group will develop good research practice recommendations for the conduct of medication adherence and treatment persistence research studies and will provide insight, through systematic reviews of the medication adherence literature, on interventions that improve medication adherence.


Elizabeth Manias, RPh, RN, PhD

Research Professor, Deakin University
Kew, VIC, Australia

Priti Pednekar, MS, BS, PhD

Research Scientist, PRECISIONheor
Fremont, CA, United States

John Zeber, PhD

Associate Professor
Brattleboro, VT, United States

Working Groups:

Key Project

Criteria for the value assessment for medication adherence-enhancing interventions (MAEI)

PROSPERO registration number CRD42021242934


  • Tamas Agh, MD. MSc., Ph.D, Principal Researcher, Syreon Research Institute,  Budapest, Hungary 
  • Bijan Borah, MSc, PhD, Professor of Health Services Research, Mayo Clinic College of Medicine, Rochester, MN, United States  
  • Mickaël Hiligsmann, PhD, Associate Professor, Maastricht University, Maastricht, Netherlands

Member Engagement


  • Andrew Peterson, PhD, PharmD, Professor of Clinical Pharmacy and Professor of Health Policy, University of the Sciences, Philadelphia, PA , United States

Work Products

  1. Letter to the Editor: Methods for Measuring Multiple Medication Adherence: A Systematic Review and Authors reply
  2. Methods for Measuring Multiple Medication Adherence: A Systematic Review Report, Published March 2020
  3. Initial Medication Adherence - Review and Recommendations for Good Practices in Outcomes Research: An ISPOR Medication Adherence and Persistence Special Interest Group Report
  4. Hiligsmann M, Salas M, Hughes DA, Manias E, Gwadry-Sridhar FH, Linck P, Cowell W. Interventions to improve osteoporosis medication adherence and persistence: a systematic review and literature appraisal by the ISPOR Medication Adherence & Persistence Special Interest Group. Osteoporos Int. 2013 Dec;24(12):2907-18
  5. A Systematic Literature Review of Psychosocial and Behavioral Factors Associated with Initial Medication Adherence: A Report of the ISPOR Medication Adherence & Persistence Special Interest Group
  6. Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence & Persistence Special Interest Group
  7. Costs of Medication Nonadherence in Patients with Diabetes Mellitus: A Systematic Review and Critical Analysis of the literature
  8. Gwadry-Sridhar FH, Manias E, Zhang Y, et al. A framework for planning and critiquing medication compliance and persistence research using prospective study designs. Clin Ther 2009;31:421-35. 
  9. Medication Compliance and Persistence: Terminology and Definitions
  10. Understanding Medication Compliance and Persistence from an Economics Perspective
  11. ISPOR Good Research Practices: A Checklist of Medication Compliance and Persistence Studies Using Retrospective Databases
  12. Methods for Integrating Medication Compliance and Persistence in Pharmacoeconomic Evaluations

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