Published Dec 2019
Gwadry-Sridhar FH, Manias E, Lal L, et al. Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group. Value in Health. 2013;16(5):863-871.
To systematically review the evidence on the impact of interventions to improve medication adherence in adults prescribed antihypertensive medications.
An electronic search was undertaken of articles published between 1979 and 2009, without language restriction, that focused on interventions to improve antihypertensive medication adherence among patients (≥18 years) with essential hypertension. Studies must have measured adherence as an outcome of the intervention. We followed standard guidelines for the conduct and reporting of the review and conducted a narrative synthesis of reported data.
Ninety-seven articles were identified for inclusion; 35 (35 of 97, 36.1%) examined interventions to directly improve medication adherence, and the majority (58 of 97, 59.8%) were randomized controlled trials. Thirty-four (34 of 97, 35.1%) studies reported a statistically significant improvement in medication adherence.
Interventions aimed at improving patients' knowledge of medications possess the greatest potential clinical value in improving adherence with antihypertensive therapy. However, we identified several limitations of these studies, and advise future researchers to focus on using validated adherence measures, well-designed randomized controlled trials with relevant adherence and clinical outcomes, and guidelines on the appropriate design and analysis of adherence research.
Full ContentLog In to View Report
- Medication Compliance and Persistence: Terminology and Definitions
- Costs of Medication Non adherence in Patients with Diabetes Mellitus: A Systematic Review and Critical Analysis of the Literature
- Methods for Integrating Medication Compliance and Persistence in Pharmacoeconomic Evaluations
- Methods for Measuring Multiple Medication Adherence: A Systematic Review
- Initial Medication Adherence - Review and Recommendations for Good Practices in Outcomes Research: An ISPOR Medication Adherence and Persistence Special Interest Group Report
- Systematic Literature Review of Psychosocial and Behavioral Factors Associated with Initial Medication Adherence
- Understanding Medication Compliance and Persistence from an Economics Perspective
- Checklist for Medication Compliance and Persistence Studies Using Retrospective Databases