Criteria for Value Assessment of Medication Adherence-Enhancing Interventions: Preliminary Results of a Systematic Review


Agh T1, Hiligsmann M2, Jakab I3, Beaudart C2, Manias E4, Borah B5, Pednekar P6, Zeber J7, Turcu-Stiolica A8, Daly C9, Shah C10, Atal S11, Sharma M12, Zhao Y13, Dimitrova M14, Kamat S15, Milky G16, Hutchinson D17, Gangan N18, Unni E19, Brzozowska M20, Hajimiri SH21, Janodia M22, Peterson A23
1Syreon Research Institute, Budapest, Hungary, 2Maastricht University, Maastricht, LI, Netherlands, 3Independent patient advocate, Budapest, Hungary, 4Deakin University, Kew, VIC, Australia, 5Mayo Clinic College of Medicine, Rochester, MN, USA, 6PRECISIONheor, Fremont, CA, USA, 7University of Massachusetts Amherst, Amherst, MA, USA, 8Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova, DJ, Romania, 9University at Buffalo, Buffalo, NY, USA, 10University of Marylnad, Baltimore, MD, USA, 11All India Institute of Medical Sciences (AIIMS) Bhopal, Bhopal, India, 12The University of Mississippi, University, MS, USA, 13Xavier University of Louisiana, New Orleans, LA, USA, 14Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria, 15University of Rhode Island, Kingston, RI, USA, 16Purdue University, Milpitas, CA, USA, 17PCVS Health, Scottsdale, AZ, USA, 18HealthCore, Inc., Wilmington, DE, USA, 19Touro College of Pharmacy, New York, NY, USA, 20Medical University of Lodz, Warsaw, MZ, Poland, 21Tehran University of Medical Sciences, Tehran, Iran, 22Manipal Academy of Higher Education, Manipal, KA, India, 23Saint Joseph's University, Philadelphia, PA, USA

Presentation Documents

OBJECTIVES: Medication non-adherence is prevalent across all clinical conditions and causes major medical and economic challenges. While medication adherence enhancing interventions (MAEIs) have demonstrated proven benefits in improving outcomes, to date there is no comprehensive overview on the assessment of these interventions. This study aimed to fill this gap by systematically collect outcome measures used for the value assessment of MAEIs.

METHODS: Systematic literature review was performed using MEDLINE (via OVID), PsycINFO (via OVID), Scopus, CINAHL (via EBSCO), and Academic Search Complete (via EBSCO). We extracted data on outcome measures reported in relevant clinical trials, prospective cohort studies and economic evaluations published in English language papers between 2018 and 2020. The protocol was registered with the PROSPERO, in accordance to PRISMA guidelines (CRD42021242934).

RESULTS: Title and abstracts of 14,685 records were screened, resulting in 1,782 potentially eligible articles for full-text screening. In total, 308 articles were included in the data extraction. Of the included studies, 91 involved behavioral components, 110 used educational strategies and 107 provided mixed educational and behavioral interventions for improving adherence. The median (IQR) number of outcomes per study used to assess the effectiveness of MAEIs was 3 (2). The identified outcome measures were clustered into 6 categories: medication adherence (measured in 233 studies), patient-reported (n=134), clinical (n=127), resource utilization (n=40), economic (n=19) and other outcomes (n=54).

CONCLUSIONS: While a variety of outcomes were used to assess MAEIs, many were considered secondary outcomes. Besides adherence, clinical and patient-reported outcomes, only a limited number of studies measured the impact of MAEIs on resource utilization and economic outcomes. Further studies would be warranted to select and rank the most relevant outcome measures for the value assessment of MAEIs.

Conference/Value in Health Info

2022-11, ISPOR Europe 2022, Vienna, Austria

Value in Health, Volume 25, Issue 12S (December 2022)




Patient-Centered Research, Study Approaches

Topic Subcategory

Adherence, Persistence, & Compliance, Literature Review & Synthesis


No Additional Disease & Conditions/Specialized Treatment Areas

Your browser is out-of-date

ISPOR recommends that you update your browser for more security, speed and the best experience on Update my browser now