ISPOR Health Science and Policy Initiatives News

Published Nov 17, 2022

New ISPOR Reports  

  1. The Clinical Outcomes Assessment Special Interest Group will published a paper, titled “Guiding Principles for Using COAs in Real World Studies: What to do when there is no regulatory guidance” in the July/August issues of Value & Outcomes Spotlight. 
  2. The ISPOR HTA Council Working Group on Challenges of HTA in Pluralistic Healthcare Systems published a new paper, Challenges of Health Technology Assessment in Pluralistic Healthcare Systems: An ISPOR Council Report, in the August issue of Value in Health.  
  3. The ISPOR Clinical Outcome Assessment Special Interest Group published a new paper, “Is IQWiG's 15% Threshold Universally Applicable in Assessing the Clinical Relevance of Patient-Reported Outcomes Changes? An ISPOR Special Interest Group Report” in the September issue of Value in Health.  
  4. The ISPOR Digital Health Special Interest Group published a new paper, titled “How Useful Are Digital Health Terms for Outcomes Research? An ISPOR Special Interest Group Report” in the September issue of Value in Health.  
  5. The ISPOR Medical Devices and Diagnostics Special Interest Group recently published a manuscript titled, “Generating Appropriate and Reliable Evidence for Value Assessment of Medical Devices: An ISPOR Medical Devices and Diagnostics Special Interest Group Report” in the Journal of Medical Devices.  

Recent Events  

  1. ISPOR HTA Roundtable – Latin America – Summary  

    Summary developed by Sebastian Garcia Marti, Chair of ISPOR HTA Roundtable Latin America

    On 28 July 2022, ISPOR virtually held the ISPOR Health Technology Assessment (HTA) Roundtable – Latin America where 30 participants from different countries around the region convened to discuss how to incorporate economic evidence into health technologies assessment process and the challenges of HTA in pluralistic societies. 

    ISPOR has been convening annual Health Technology Assessment (HTA) Roundtables since 2007 with Roundtables now held in Asia Pacific, Europe, North America, Middle East and Africa, and Latin America. These Roundtables are closed-door, invitation only meetings between HTA bodies, public and private payers, other governmental decision makers, and academics when no HTA body exists in a country. They provide an unbiased platform to advance scientific methods; facilitate information-sharing about the current state of HTA, its development, and its role in optimizing healthcare decisions; and bridge the gap between technology assessors, private and public payers, regulators, and patients to improve health globally. 

    More specifically, the HTA Roundtable in Latin America is comprised of HTA bodies and other governmental organizations involved in pricing and reimbursement of healthcare technologies in Latin America. 

    During the meeting on 28 July, Andrés Pichon-Riviere from the Institute for Clinical Effectives and Health Policy (IECS) in Argentina, Adriana Robayo from the Instituto de Evaluación Tecnologica en Salud (IETS), and Aurelio Mejía from Ministerio de Comercio, Industria y Turismo (MINCIT) in Colombia presented some concepts around the incorporation of economic evidence in health technology assessments review, the experience in measuring a cost-effectiveness threshold for Colombia, and concepts on HTA process in pluralistic societies. 

    Andrés Pichon Riviere presented some of the results of the Inter-American Development Bank (IADB) Project report “Application of economic evidence in health technology assessment and decision-making for the allocation of health resources in Latin America: Seven key topics and a preliminary proposal for implementation” (1). He mentioned that two common regional barriers at the moment to incorporate economic evidence are lack of local economic evidence and countries not having a cost-effectiveness threshold defined. Regarding the cost-effectiveness thresholds, he presented some work on the estimation of local thresholds derived from country level life expectancy and GDP per capita. Results were similar to other studies’ results with general values around or less 1 GDP per capita for the different countries in the region. He also presented some approximation for the incorporation of economic evidence from other countries that rely on the comparison of GDP per capita of the country where the economic evidence was generated and the country where it needs to be incorporated, by relating the benefit and cost of the technology in both countries, the original and the application one. 

    Adriana Robayo presented a project done in Colombia to estimate the cost-effectiveness threshold. Based on mortality individual level data national vital health statistics, general life expectancy and national healthcare expenditure they estimate a threshold for Colombia of around 0.86 GDP per capita per QALY and 0.75 per life year gained, similar to the estimations in other studies (2).  She also proposed some potential applications of this threshold as HTA price regulation and incorporation into the national health system. 

    During the second half of the Roundtable, Aurelio Mejía presented the work done by the ISPOR HTA Council Working Group on the Challenges of HTA in Pluralistic Healthcare Systems (3). It was highlighted that the challenges that this kind of health system face are multiple payers or funders with different requirements of information, different budgets, and different responsibilities regarding the provision of care. 

    He proposed some suggestions to overcome these challenges that includes the development of some core methods shared by the different payers or funders, the promotion of local adaptation of HTAs to facilitate its application, the generation of HTAs timely in accordance with the decisions to be made and to develop and maintain a collaborative framework that generates and promotes transparency among the different actors in the health system. 

    The roundtable concluded with HTA Council Chair and ISPOR President-Elect 2022-2023, Brian O’Rourke inviting the participation to the next ISPOR HTA Roundtable to be held virtually in July 2023. 

    (1)   Application of economic evidence in health technology assessment and decision-making for the allocation of health resources in Latin America: Seven key topics and a preliminary proposal for implementation. A report for the Inter-American Development Bank. Pichon-Riviere A, Drummond M, García Marti S, Augustovski F. July 2021. IDB-TN-2286. July 2021. DOI http://dx.doi.org/10.18235/0003649. Available in eprints from: https://eprints.whiterose.ac.uk/178985/ 

    (2)   Espinosa O, Rodríguez-Lesmes P, Orozco L, Ávila D, Enríquez H, Romano G, Ceballos M. Estimating cost-effectiveness thresholds under a managed healthcare system: experiences from Colombia. Health Policy Plan. 2022 Mar 4;37(3):359-368. 

    (3)   Drummond MF, Augustovski F, Bhattacharyya D, Campbell J, Chaiyakanapruk N, Chen Y, Galindo-Suarez RM, Guerino J, Mejía A, Mujoomdar M, Ollendorf D, Ronquest N, Torbica A, Tsiao E, Watkins J, Yeung K; ISPOR HTA Council Working Group on HTA in Pluralistic Healthcare Systems collaborators. Challenges of Health Technology Assessment in Pluralistic Healthcare Systems: An ISPOR Council Report. Value Health. 2022 Aug;25(8):1257-1267. 

     

  2. The ISPOR Virtual Payer Summit 2022 was hosted on Thursday, September 15. The theme of this year’s Summit was “Value Interpretation: Do We Need to Expand the Concept of Value for High-Cost Innovations?”. This discussion was coupled with breakout sessions that discussed avoided vs avoidable costs, incorporating patient-centered research and endpoints into value assessment, and how to incorporate broader societal value into clinical and economic assessments. 

     

    This event was moderated by Carole Longson, PhD of Carole Longson Consulting. Panelists included Peter Neumann, ScD of Tufts Medical Center, Alan J. Balch, PhD, of the Patient Advocate Foundation and National Patient Advocate Foundation, and Iga Lipska, MD, PhD, MPH of the Medical University of Gdańsk.  

    The topics featured at the Payer Summit were identified and led by experts from payers, industry, and academia who follow emerging trends and challenges in healthcare decision making. This meeting convened over 30 participants from payers, HTA bodies, patient organizations, and the biopharmaceutical industry to share lessons learned, solutions, and priorities for moving forward.  

    Additional information on the ISPOR Payer Summits is available here: https://www.ispor.org/strategic-initiatives/payer-engagement-in-heor  

  3. The 2022 ISPOR Health Technology Assessment (HTA) Roundtable–Asia Pacific was hosted virtually on Tuesday, 27 September. Over 30 participants partook in the event, including HTA bodies, public and private payers, other governmental decision makers, & academics. Topics covered include the role of HTA in rebuilding the healthcare system post-pandemic and a review of a journal article about an HTA implementation scorecard for the Asia Region

     

    This Roundtable was Chaired by Izzuna Mudla Mohamed Ghazali, MBBS, MPH. To access the HTA Roundtable webpage click here: https://www.ispor.org/member-groups/councils-roundtables/health-technology-assessment-council/health-technology-assessment-roundtables  

  4. The 2022 ISPOR Health Technology Assessment (HTA) Roundtable–Middle East & Africa was held virtually on Tuesday, 4 October. Over 40 participants partook in the event, including HTA bodies, public and private payers, other governmental decision makers, & academics from 23 countries. Topics covered include implementing Consolidated Health Economic Evaluating Reporting Standards (CHEERS) 2022 into country evaluations, current status of HTA globally and institutionalizing HTA, and how international collaboration can improve decision making.   

     

    This Roundtable was Chaired by Brian O'Rourke, PharmD as a request by the Chair of the ISPOR HTA Roundtable – Middle East and Africa, Mouna Jameleddine, PharmD, MSc. To access the HTA Roundtable webpage click here: https://www.ispor.org/member-groups/councils-roundtables/health-technology-assessment-council/health-technology-assessment-roundtables  

  5. The ISPOR Health Technology Assessment (HTA) Roundtable – Europe was hosted on Sunday, 6 November in Vienna, Austria. Over 60 participants partook in the event, including HTA bodies, public and private payers, other governmental decision makers, & academics when no HTA body exists in the country. Topics covered include HTA updates from Europe, HTA and public health in a time of crisis, speed versus quality, and a discussion of hot topics.  

This Roundtable was chaired by Iga Lipska, MD, PhD, MPH and Máirín Ryan, PhD. To access the HTA Roundtable webpage click here: https://www.ispor.org/member-groups/councils-roundtables/health-technology-assessment-council/health-technology-assessment-roundtables 

Recent Webinars Available for On-Demand Viewing 

  1. The Health Preference Research Special Interest Group hosted a webinar in September, titled “Differentiating Between Patient Preferences, Patient Reported Outcomes and Patient Engagement”. Click here to view the recording. 
  2. The Statistical Methods in HEOR Special Interest Group hosted a webinar in September, titled “An Introduction to Network Meta-Analysis”. Click here to view the recording. 
  3. The Clinical Outcome Assessment Special Interest Group hosted a webinar in September, titled “ Clinical Outcome Assessments in the Asia Pacific Region: Strategy & Implementation”. Click here to view the recording.
  4. The Statistical Methods in HEOR Special Interest Group hosted a webinar in September, titled “Network Meta-Analysis - Special Topics”. Click here to view the recording. 
  5. The Clinical Outcome Assessment Special Interest Group hosted a webinar in October, titled “Achieving Fit for Purpose Data from Wearables for Age-Related Diseases”. Click here to view the recording. 

New Opportunities  

  1. ISPOR member groups have conducted live journal clubs—focused discussions on specific, published, scientific research papers—on topics related to health equity research, open source models, precision medicine and advanced therapies, in addition to other timely topics. Recently added Journal Club recordings include: 
  1. Simulating Progression-Free and Overall Survival for First-Line Doublet Chemotherapy with or without Bevacizumab in Metastatic Colorectal Cancer Patients Based on Real-World Registry Data” [ISPOR Open Source Models Special Interest Group]
  2. Use of Real- World Evidence to Drive Drug Development Strategy and Inform Clinical Trial Design
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