OBJECTIVES: Polymyalgia Rheumatica (PMR) is an inflammatory rheumatic disorder characterized by muscle pain and stiffness in the neck, shoulder, and pelvic girdle. Glucocorticoids (GC) are the standard of care; however, there is a need for new GC-sparing treatments to sustain remission and improve safety. The aim of this study was to identify, and summarize existing literature on economic evaluations, health-related quality of life (HRQoL), healthcare resource utilization (HCRU) and costs in adult patients with PMR and identify knowledge gaps.

METHODS: A targeted literature review was conducted in July 2023. Search strategies were implemented in MEDLINE, EMBASE, Cochrane, HTA and NHS economic evaluation databases. Hand searches on HTA websites, clinical trial registries and key congresses were also performed. Study selection, data extraction and reporting of findings was conducted using current best practices.

RESULTS: A total of 41 publications were included. No economic evaluation was identified. Review of HCRU and cost studies (n= 11) encompassed five countries and revealed that HCRU was higher in individuals with PMR compared to a non-PMR group and higher in those individuals with a relapse compared to those without. Direct medical cost of managing PMR was higher compared to non-PMR cases and higher for individuals with PMR and a concomitant giant cell arteritis diagnosis compared to those without. No evidence on impact on work productivity or indirect costs was identified. HRQoL/utility studies (n=30) demonstrated impaired HRQoL for individuals with PMR though evidence in different disease stages (health states) was scarce. No study on the impact on families and caregiver burden was identified; nor data by different disease stages that would allow economic modelling.

CONCLUSIONS: Though the literature is limited, the findings suggest there is a high impact on HRQoL among patients with PMR. Further research is required to understand the extent of the economic, humanistic, and caregiver burden associated with PMR.