OBJECTIVES:: In Brazil, digitalized real world data (RWD) sources are scarce. Some electronic medical records’ (EMRs) systems are currently being implemented, but most of them are still in an early phase. EMRs and claim data have an important role in generating RWD (especially when compared with classical retrospective studies) due to their ability to compile data on large samples of patients and to speed up study conduction. This study aims to assess and compare the profile of patients from two different cancer claims databases in Brazil (Auditron and FOSP). METHODS:: Auditron is an auditing claims database of the private healthcare setting and FOSP database includes all cancer diagnoses of 76 institutions in the state of São Paulo. In order to compare both databases, we considered only FOSP patients that underwent chemotherapy and/or hormone therapy, once imported data from Auditron referred exclusively to oncology prescriptions. For both FOSP and Auditron databases, we analyzed data for the year 2015 from the state of Sao Paulo. Descriptive analyses were performed based on the most common types of tumors. RESULTS::  We identified 14,742 patients in FOSP database and 1,519 patients with 2,835 prescriptions in Auditron database. Among FOSP patients, 13,554 and 1,189 were from the public and private settings, respectively, while all Auditron patients were from the private setting. The most common cancer types were breast cancer (24.9%, n=3,662), prostate cancer (8.5%, n=1,254), and lung cancer (6.1%, n=892) in FOSP, and breast cancer (29.1%, n=823), prostate cancer (11.6%, n=328), and myeloid leukemia (9.3%, n=263) in Auditron. CONCLUSIONS::  Although limited to the state of Sao Paulo, FOSP database provides substantial information on cancer treatment, from a large number of patients. Auditron presents a larger geographic coverage on the country and more detailed information on prescriptions, while FOSP does not provide detailed information on prescriptions.