EQ-5D STUDIES IN DISEASES OF THE CIRCULATORY SYSTEM IN EIGHT CENTRAL AND EASTERN EUROPEAN COUNTRIES
Golicki D1, Péntek M2, Gulácsi L2, Prevolnik Rupel V3, Simon J4, Brodszky V2, Baji P2, Zrubka Z2, Závada J5, Petrova G6, Rotar A7, Rencz F2
1Department of Clinical & Experimental Pharmacology, Medical University of Warsaw, Warsaw, Poland, 2Corvinus University of Budapest, Budapest, Hungary, 3Institute for Economic Research, Ljubljana, Slovenia, 4Medical University of Vienna, Vienna, Austria, 5Institute of Rheumatology, Prague, Czech Republic, 6Medical University Sofia, Faculty of Pharmacy, and President, ISPOR Bulgaria Chapter, Sofia, Bulgaria, 7University of Amsterdam, Amsterdam, The Netherlands
OBJECTIVES: To systematically review studies with the use of the EQ-5D within circulatory system diseases, performed in Central and Eastern European (CEE) countries. METHODS: We performed a systematic literature search using PubMed, EMBASE, Web of Science, CINAHL, PsycINFO, The Cochrane Library and the EuroQol Group database up to July 1, 2015. Local journals were also handsearched. Full-text articles reporting original research with EQ-5D instruments from Austria, Bulgaria, Czech Republic, Hungary, Poland, Romania, Slovakia and Slovenia were included. Studies on diseases of the circulatory system were selected and analysed. RESULTS: From the 143 identified references on EQ-5D in CEE countries, 30 papers on 9429 patients dealt with conditions of the circulatory system. Most of studies were performed in Poland (18) or Czech Republic (7). Described conditions included: ischaemic heart disease (number of studies N=14; number of participants n=6541), arrhythmias (N=4; n=897), peripheral arterial occlusive disease (N=4; n=235), stroke (N=3; n=580), hypertension (N=2; n=654), aortic stenosis (N=2; n=85) and vein surgery (N=1; n=437). Majority of studies were prospective cohort (13) or cross-sectional (12) in nature and were performed as an on-site survey (29). Five level EQ-5D (EQ-5D-5L) was used in three studies, and EQ-5D-Y in none. EQ-5D utility scores were reported in 12 (40%) papers and they were based on UK, Polish, European or Slovenian tariff (4, 4, 3, 1 studies, respectively). CONCLUSIONS: The area of circulatory system diseases is the largest field of activity in EQ-5D studies in Central and Eastern Europe. Our results provide a basis to develop a regional EQ-5D database and a reseach agenda for cardiovascular centres both at the national and regional level.
Conference/Value in Health Info
2016-10, ISPOR Europe 2016, Vienna, Austria
Value in Health, Vol. 19, No. 7 (November 2016)
Health State Utilities