OBJECTIVES:  To systematically review studies with the use of the EQ-5D within circulatory system diseases, performed in Central and Eastern European (CEE) countries. METHODS:  We performed a systematic literature search using PubMed, EMBASE, Web of Science, CINAHL, PsycINFO, The Cochrane Library and the EuroQol Group database up to July 1, 2015. Local journals were also handsearched. Full-text articles reporting original research with EQ-5D instruments from Austria, Bulgaria, Czech Republic, Hungary, Poland, Romania, Slovakia and Slovenia were included. Studies on diseases of the circulatory system were selected and analysed. RESULTS:  From the 143 identified references on EQ-5D in CEE countries, 30 papers on 9429 patients dealt with conditions of the circulatory system. Most of studies were performed in Poland (18) or Czech Republic (7). Described conditions included: ischaemic heart disease (number of studies N=14; number of participants n=6541), arrhythmias (N=4; n=897), peripheral arterial occlusive disease (N=4; n=235), stroke (N=3; n=580), hypertension (N=2; n=654), aortic stenosis (N=2; n=85) and vein surgery (N=1; n=437). Majority of studies were prospective cohort (13) or cross-sectional (12) in nature and were performed as an on-site survey (29). Five level EQ-5D (EQ-5D-5L) was used in three studies, and EQ-5D-Y in none. EQ-5D utility scores were reported in 12 (40%) papers and they were based on UK, Polish, European or Slovenian tariff (4, 4, 3, 1 studies, respectively). CONCLUSIONS: The area of circulatory system diseases is the largest field of activity in EQ-5D studies in Central and Eastern Europe. Our results provide a basis to develop a regional EQ-5D database and a reseach agenda for cardiovascular centres both at the national and regional level.