Health Related Quality of Life and Health Utility Values Across Different Levels of Physically Distancing Behaviors to Avoid COVID-19 in Immunocompromised Adults – The Eagle Study
Author(s)
Lloyd A1, Arnetorp S2, Marcus J3, Yokota RTC4, Herring TA5, Powell PA6, Rohay J7, Severens JL8, Venkatesan S9, Williams P10, Maia T11, Taylor S9, Krol M12, Ware Jr. JE13
1Acaster Lloyd Consulting Ltd, Oxford, Oxfordshire, UK, 2AstraZeneca, Gothenberg, Västergötland, Sweden, 3IQVIA, US, Washington, DC, USA, 4P95, Leuven, Flemish Brabant, Belgium, 5AstraZeneca, Wilmington, DE, USA, 6University of Sheffield, Sheffield, UK, 7IQVIA, Pittsburgh, PA, USA, 8Severens HTA Consultancy, Venray, Limburg, Netherlands, 9AstraZeneca, Cambridge, Cambridgeshire, UK, 10IQVIA, Courbevoie, Île-de-France, France, 11IQVIA, Porto Salvo, Oeiras, Portugal, 12IQVIA, Amsterdam, ZH, Netherlands, 13John Ware Research Group, Worcester, MA, USA
OBJECTIVES: To reduce the risk of COVID-19 severe outcomes, immunocompromised (IC) individuals were recommended to physically distance, potentially impacting their health-related quality of life (HRQoL). This study evaluated HRQoL outcomes across different levels of physically distancing (PD) to avoid COVID-19 in IC adults.
METHODS: A cross-sectional, online survey study (EAGLE Study) was conducted (December 2022-June 2023) in IC and non-IC adults (US and UK). HRQoL outcomes included: health utilities (EQ-5D-5L and SF-6D); anxiety and depression scores (HADS); productivity loss (WPAI+CIQ:SHP). Past 4-week PD behaviors were assessed using the Physical Distancing Scale-COVID-19 (PDS-C19), validated in a subsample of EAGLE. Descriptive analyses were conducted across PD groups (Very Low/Low/Moderate/High), defined from the PDS-C19 score.
RESULTS: 2,679 adults completed the survey (IC: 86.6%; non-IC: 13.4%). PD to avoid COVID-19 was reported by 67.9% of IC (and 41.2% of non-IC) adults. Among IC adults, no differences were observed across PD levels in the distribution of gender, age, had received ≥ 3 COVID-19 vaccine doses, ≥1 comorbidity, and type of IC condition. In IC adults, the mean differences between the lowest and highest levels of PD in health utilities were 0.27 (35% lower) for EQ-5D-5L and 0.15 (21% lower) for SF-6D and in HADS scores (2-fold higher) were 5.22 (anxiety) and 5.30 (depression). In IC adults, important differences in productivity loss were observed between lowest and highest PD levels: proportion employed (PD-very low: 57.5%; PD-high: 34.9%), absenteeism (PD-very low: 2.0%; PD-high: 23.7%) and presenteeism (PD-very low: 4.2%; PD-high: 34.8%).
CONCLUSIONS: After governmental shielding recommendations for the general population were lifted, approximately two-thirds of IC adults reported physically distancing themselves to avoid COVID-19. Lower utilities, employment, presenteeism, and higher anxiety, depression, and absenteeism, were observed in IC adults who practiced PD behaviors, demonstrating that COVID-19 remains a burden for IC individuals.
Conference/Value in Health Info
Value in Health, Volume 26, Issue 11, S2 (December 2023)
Code
PCR226
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities, Patient-reported Outcomes & Quality of Life Outcomes
Disease
Infectious Disease (non-vaccine), No Additional Disease & Conditions/Specialized Treatment Areas