PURPOSE: Longitudinal qualitative research (LQR)—where the same participants are interviewed multiple times and data analyzed longitudinally to characterize changes over time—can provide unique insights in clinical trial and real world settings, such as characterizing meaningful treatment benefit for the population under study and understanding disease trajectory to describe the course or progression of disease. However, LQR is underutilized and/or poorly reported in many domains of patient outcome research. Understanding the current state of LQR methods and potential applications can help guide the expansion of this methodological approach in the health outcomes research domain. This workshop will provide insights on benefits and potential challenges of LQR and provide opportunities to learn about methodological approaches for collecting and analyzing longitudinal qualitative data in clinical trials and real-world studies.

DESCRIPTION: After an introduction of LQR purpose and current methodological approaches, the speakers will present potential applications and examples of LQR in clinical trial and real-world settings and address resulting contributions to patient centered outcomes research in each case study.

• Introduction to LQR, potential applications and value to stakeholders (10 min)
• Designing LQR studies and practical challenges (10 min)
• Potential real-world LQR opportunities using ovarian and breast cancer cases studies as examples (10 min)
• Case study on the use of longitudinal mixed methods approach to assess treatment benefit in Migraine in the context of a clinical trial (10 min)

• Understand the benefits of LQR data and their value in drug development and real-world settings
• Understand methodological approaches to implement LQR and potential challenges
• Discuss potential applications and outcomes of LQR in patient outcome research