A Budget Impact Analysis of Introducing a New Combination of Atorvastatin and Ezetimibe in Greece

Author(s)

Koulentaki M1, Gourzoulidis G1, Chotzagiannoglou V2, Beletsi A2, Kourlaba G1
1Econcare LP, Athens, A1, Greece, 2SERVIER HELLAS Pharmaceuticals LTD, Athens, A1, Greece

Presentation Documents

OBJECTIVES: To investigate the budgetary impact from the introduction of a new combination of ezetimibe and atorvastatin (EZE/ATOR_CH [Cholzet]), as adjunct to diet for treatment in primary hypercholesterolaemia in patients who are not appropriately controlled with a statin alone or in whom a statin is considered inappropriate or is not tolerated.

METHODS: A budget impact model was developed from a public payer perspective, to delineate the financial implications of ΕΖΕ/ΑΤΟR_CH inclusion in the Greek healthcare market comparing a current (world without ΕΖΕ/ΑΤΟR_CH) with a future scenario (world with ΕΖΕ/ΑΤΟR_CH), over the next 5 years. The analysis compares all fixed-dose combination of ΕΖΕ/ΑΤΟR reimbursed in Greece and pharma’s projection estimates were used for building up the market shares of the analyses. Epidemiological data from published literature and market’s sales were used to estimate the number of eligible patients. Costs related to drug acquisition and adverse events were considered in the analysis and were retrieved from the latest medicines’ reimbursement list, issued by the Greek Ministry of Health and published literature (€,2022). Τhe measured outcomes were incremental cost and total budget impact, calculated by comparing the respective budget expenditures with and without ΕΖΕ/ΑΤΟR_CH in the market share mix scenarios.

RESULTS: The total number of patients treated with EZE/ATOR was 74,131 (year 1 of analysis) and the number of patients who received ΕΖΕ/ΑΤΟR_CH was 8,011, 11,065, 12,704, 13,319 and 14,385 from year 1 to 5, respectively. The analysis showed that adding ΕΖΕ/ΑΤΟR_CH to the market resulted to an average (annually) budget savings of 2,429,206€. Over the 5-year time horizon, adding ΕΖΕ/ΑΤΟR_CH to the market resulted in considerable cost-savings with a total budget impact of -12,146,032€.

CONCLUSIONS: The analysis suggests that the introduction of ΕΖΕ/ΑΤΟR_CH in the Greek market is expected to bring significant economic benefit for the Greek public payer.

Conference/Value in Health Info

2022-11, ISPOR Europe 2022, Vienna, Austria

Value in Health, Volume 25, Issue 12S (December 2022)

Code

EE418

Topic

Economic Evaluation, Epidemiology & Public Health

Topic Subcategory

Budget Impact Analysis

Disease

SDC: Cardiovascular Disorders (including MI, Stroke, Circulatory)

Explore Related HEOR by Topic


Your browser is out-of-date

ISPOR recommends that you update your browser for more security, speed and the best experience on ispor.org. Update my browser now

×