Presentation (CTI)

OBJECTIVES: Osteoporosis is one of the metabolic diseases of the bone. Due to the complexity of the healing process, the treatment of osteoporotic fractures is one of the important problems of modern traumatology. Diagnostic markers are needed to monitor the healing period. Human cartilage glycoprotein -39, which has been studied so far in inflammatory processes in bones, may allow the development of correct treatment reflecting the level of metabolic processes in bone tissue.
METHODS:
The study was performed to examine the dynamics of human cartilage glycoprotein-39 (HCgp39) in the blood serum during osteoporosis and fracture healing. The material of the study is formed by the examination results of 68 people aged 38-83. Group I - control group consisted of 14 practically healthy people, group II - 14 patients with osteoporosis, group III-15 patients with non-osteoporotic fractures, group IV - 25 patients with osteoporotic fractures. The level ofthis indicator was observed in dynamics 3 times during the first month. Statistical analysis of the obtained indicator was carried out using the SPSS 22.0 package.
RESULTS:
As a result, in the first month of the recovery period, the concentration of HCgp39 decreased in the blood serum of osteoporotic patients by 2.0 times compared to the control, but increased by 13.9% and 30.3% in patients with osteoporotic fractures and non-osteoporotic patients, respectively. This proves its role in the pathogenesis of fractures. The treatment period for patients with osteoporosis and osteoporotic fractures did not change significantly for HCgp39 concentration, while in non-osteoporotic subjects it decreased significantly by 30.0%.
CONCLUSIONS:
HCgp39, a regulator of bone and cartilage metabolism, is significantly increased in osteoporotic fractures. However, the decrease in HCgp39 suggests that it is an important and informative factor in the fracture healing process after treatment.