Comparison of the Effectiveness of Defocus Spectacle Lenses in Slowing Myopia Progression: A Retrospective Cohort Study
Author(s)
Zixuan Wang, B.S.1, Shaocun Huang, B.S.2, Xiaoqin Chen, M.Sc.2, Lihua Li, B.S.2, Tiejing Sun, M.Sc.2, Chang Luo, M.Sc.1, Shitong Xie, Ph.D.1.
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China; Center for Social Science Survey and Data, Tianjin University, Tianjin, China, 2Tianjin Eye hospital, Tianjin, China; Tianjin Eye Hospital Optometric center, Tianjin, China.
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China; Center for Social Science Survey and Data, Tianjin University, Tianjin, China, 2Tianjin Eye hospital, Tianjin, China; Tianjin Eye Hospital Optometric center, Tianjin, China.
OBJECTIVES: Defocus Incorporated Multiple Segments (DIMS), Highly Aspherical Lenslets (HAL), Peripheral Defocus (PD), and Asymmetric Peripheral Defocus (APD) are the defocus spectacle lenses most commonly used for myopia control. This retrospective cohort study aimed to compare their effectiveness in patients with myopia.
METHODS: We included myopia patients with treatment records for DIMS, HAL, PD, APD, or single-vision (SV) spectacle lenses from Tianjin Eye Hospital, China. Patient records include demographics, eye-using habits, and optometry data. Changes in spherical equivalent refraction (SER) and axial length (AL) from baseline to 12-month follow-up were adopted to assess the myopia progression. Overlap weighting using propensity scores was applied to adjust for potential confounders. Paired comparisons among the five types of spectacle lenses were performed.
RESULTS: A total of 633 patients were included: 213 with DIMS, 78 with HAL, 102 with PD, 169 with APD, and 71 with SV. The mean [SD] age was 11.32 [2.26] years, and 304 [48.03%] were female. After overlap weighting, DIMS spectacle lenses significantly reduced myopia progression compared with SV (mean difference = SER: 0.28±0.06D, AL: -0.14±0.03mm, p < 0.001), PD (mean difference = SER: 0.24±0.05D, AL: -0.12±0.03mm, p < 0.001), and APD (mean difference = SER: 0.20±0.04D, AL: 0.10±0.03mm, p < 0.001). HAL spectacle lenses significantly reduced myopia progression compared with SV (mean difference =SER: 0.40±0.08D, AL: -0.22±0.03mm, p < 0.001), PD (mean difference = SER: 0.37±0.07D, AL: -0.20±0.03mm, p < 0.001), and APD (mean difference = SER: 0.33±0.06D, AL: -0.18±0.03mm, p < 0.001). No significant differences were found in other paired comparisons.
CONCLUSIONS: In this study, DIMS and HAL spectacle lenses were more effective in slowing myopia progression compared with SV, PD, and APD spectacle lenses. The findings may inform decisions for defocus spectacle lenses selection for myopia control.
METHODS: We included myopia patients with treatment records for DIMS, HAL, PD, APD, or single-vision (SV) spectacle lenses from Tianjin Eye Hospital, China. Patient records include demographics, eye-using habits, and optometry data. Changes in spherical equivalent refraction (SER) and axial length (AL) from baseline to 12-month follow-up were adopted to assess the myopia progression. Overlap weighting using propensity scores was applied to adjust for potential confounders. Paired comparisons among the five types of spectacle lenses were performed.
RESULTS: A total of 633 patients were included: 213 with DIMS, 78 with HAL, 102 with PD, 169 with APD, and 71 with SV. The mean [SD] age was 11.32 [2.26] years, and 304 [48.03%] were female. After overlap weighting, DIMS spectacle lenses significantly reduced myopia progression compared with SV (mean difference = SER: 0.28±0.06D, AL: -0.14±0.03mm, p < 0.001), PD (mean difference = SER: 0.24±0.05D, AL: -0.12±0.03mm, p < 0.001), and APD (mean difference = SER: 0.20±0.04D, AL: 0.10±0.03mm, p < 0.001). HAL spectacle lenses significantly reduced myopia progression compared with SV (mean difference =SER: 0.40±0.08D, AL: -0.22±0.03mm, p < 0.001), PD (mean difference = SER: 0.37±0.07D, AL: -0.20±0.03mm, p < 0.001), and APD (mean difference = SER: 0.33±0.06D, AL: -0.18±0.03mm, p < 0.001). No significant differences were found in other paired comparisons.
CONCLUSIONS: In this study, DIMS and HAL spectacle lenses were more effective in slowing myopia progression compared with SV, PD, and APD spectacle lenses. The findings may inform decisions for defocus spectacle lenses selection for myopia control.
Conference/Value in Health Info
2025-09, ISPOR Real-World Evidence Summit 2025, Tokyo, Japan
Value in Health Regional, Volume 49S (September 2025)
Code
RWD121
Topic Subcategory
Health & Insurance Records Systems
Disease
SDC: Sensory System Disorders (Ear, Eye, Dental, Skin)