Qualitative Research to Understand the Lived Experience of Patients with Dry Eye Disease (DED), Meibomian Gland Dysfunction (MGD), and Sjogren's Syndrome Dry Eye Disease (SS-DED)
Author(s)
Sloesen B1, Young A2, Tinsley K3, Sharp R3, Walsh O4, Naujoks C5, Sharma G6, O'Brien P7, Bentley S8
1Novartis Pharma NV, Vilvoorde, Belgium, 2Adelphi Values Ltd, Bollington, UK, 3Adelphi Values Ltd, Bollington, Cheshire, UK, 4Novartis Ireland Ltd., Dublin, Ireland, 5Novartis Pharma AG, Basel, BS, Switzerland, 6Novartis Healthcare Pvt. Ltd., Hyderabad, AP, India, 7Novartis, Limerick, LK, Ireland, 8Adelphi Values Patient-Centered Outcomes Ltd., Bollington, UK
Presentation Documents
OBJECTIVES: The aim of this research was to qualitatively explore the patient experience of Dry Eye Disease (DED), Meibomian Gland Dysfunction (MGD), and Sjogren’s Dry Eye Disease (SS-DED) to identify symptom and impact concepts for a new patient-reported outcome (PRO) measure suitable for assessment of all three conditions.
METHODS: Qualitative concept elicitation interviews were conducted with 61 US adults who reported experiencing ocular symptoms due to their condition and had a physician-confirmed primary diagnosis of either DED (n=21), MGD (n=20), or SS-DED (n=20). Verbatim interview transcripts were analyzed using thematic analysis in ATLAS.ti v8 software. Findings contributed to development of a conceptual model detailing relevant symptom and impact concepts.
RESULTS: Participants had a mean age of 50 years (range 21-80 years), were mostly female (64%), and were representative of a range of races: Caucasian (n=27/61, 44%), Black/African American (n=20/61, 33%), Hispanic (n=7/61, 11%), and Asian (n=4/61, 7%). A total of 29 symptoms and 14 impacts were reported across patient interviews. Primary eye-related symptoms reported included eye dryness (n=61/61, 100%), eye irritation (n=55/61, 90%), eye itch (n=54/61, 89%), burning sensation (n=52/61, 85%), and foreign body sensation (n=51/61, 84%). Across the conditions, eye tiredness (n=51/61, 84%) and eyeball redness (n=55/61, 90%) were the most reported vision-related and physical symptoms, respectively. Aspects of daily life most impacted were using digital screens (n=46/61, 75%), driving (n=45/61, 74%), working (n=39/61, 64%), and reading (n=37/61, 61%). Other HRQoL domains impacted included emotional wellbeing (n=37/61, 62%) and social functioning (n=26/61, 43%).
CONCLUSIONS: This research provides an in-depth understanding of the patient experience of DED, MGD, and SS-DED. The results identified multiple prevalent symptoms and impacts, many of which were similar across the conditions. These patient-relevant concepts were used to support development of a new PRO measure for inclusion in future clinical trials in DED, MGD, or SS-DED.
Conference/Value in Health Info
Value in Health, Volume 25, Issue 12S (December 2022)
Code
PCR89
Topic
Clinical Outcomes, Economic Evaluation, Patient-Centered Research
Topic Subcategory
Clinical Outcomes Assessment, Instrument Development, Validation, & Translation, Patient-reported Outcomes & Quality of Life Outcomes, Work & Home Productivity - Indirect Costs
Disease
SDC: Sensory System Disorders (Ear, Eye, Dental, Skin)