OBJECTIVES : To assess demographics and outcomes amongst schizophrenia patients who have switched a-typical treatments versus non-switchers. METHODS : A cross-sectional survey was conducted in USA from January to May 2014 through the Adelphi Schizophrenia Disease Specific Programme. Inclusion criteria comprised hospital/office-based psychiatrists who had been practicing for 2-40 years at time of study, saw ≥6 schizophrenia patients per week and were responsible for treatment decisions. Psychiatrists provided information on their next 10 consulting schizophrenia patients aged ≥18, with the same patients invited to voluntarily complete a patient self-completion form (PSC). Patients were grouped for analysis as switchers (S) or non-switchers (NS) using their physician provided treatment history. S were patients who had switched, stopped, or added on an a-typical treatment within the last 2 years. NS had no treatment changes within the last 2 years or were in receipt of their first line which they had for at least 3 months. RESULTS : The analysis sample consisted of 395 S and 608 NS patients, some of whom also completed a PSC for select variables. On average patients were age 41 and male (54% S and 57% NS) with S more likely to have a caregiver (45% vs 28% NS p<0.001). S were more likely to have been hospitalized in the last 12 months (43% S vs 17% NS p<0.001) and for more times on average (1.7 S vs 1.3 NS p=0.0012). Physicians reported more S as severely-markedly ill according to CGI-severity scale (S 44% vs NS 25% p<0.001) and less S as much-very much improved on current treatment (CGI-improvement: S 50% vs NS 68% p<0.001). Percentage daily activity impairment due to schizophrenia calculated from WPAI scale was mean 51.0 S vs 42.9 NS (p=0.0031). CONCLUSIONS : Schizophrenia patients who had switched a-typical treatments showed significantly poorer outcomes with a higher need for caregiver support when compared to non-switchers.