Objective: To assess the preference of Brazilians for drugs with different dosing and methods of application to treat chronic diseases, such as osteoporosis. The assessed product types were: once-monthly oral, injection once every three months, and once-yearly injection. Methods: Quantitative study performed through personal and individual interviews. A representative sample of the study population (N=392 subjects) was used. Subjects over 45 years old were interviewed. A 14-item structured questionnaire was used. A card with the drug characteristics (dosing, cares of administration, side effects and annual treatment cost) was shown to the interviewed subjects. Results: Fourty-four percent of the interviewed subjects were male and 56% were female. Sixty percent of the interviewed subjects were between 45 and 59 years old, and the other 40% were 60 years old or more. Fourteen percent of the interviewed subjects belonged to the Brazilian socioeconomic classification “A”, followed by 39% in the classification “B”, and 47% in the classification “C”. Twenty-eight percent had higher education, followed by 29% with secondary education, and 42% with primary education. Ninety-three percent of the interviewed subjects do not usually take injection drugs. For treatment of chronic diseases, 72% of the patients prefer oral drugs, 16% prefer injection drugs diluted in serum, 9% prefer injection drugs, and 3% did not inform their preference. These percentages remained the same when dosing, side effects and prices were disclosed. 83% of the patients who chose oral drug did it so by convenience of the dosing, 21% of them also think that oral drugs have fewer side effects than injection drugs. Generically comparing (not considering the card with product profiles) oral and injection drugs, 78% of the population prefer oral treatments. Conclusion: If patients are given the chance to choose between oral or injection drugs to treat chronic diseases, 78% prefer oral drugs instead of injection ones.