OBJECTIVES: Examine the impact of psoriatic arthritis (PsA) clinical features on patients’ health-related quality of life (HRQoL) and assess patient and physician satisfaction with current treatment.

METHODS: Data were drawn from the Adelphi PsA Disease Specific Programme™; a real-world, point in time survey of rheumatologists and dermatologists, and their consulting patients with PsA in France, Germany, Italy, Spain, the United Kingdom and United States in 2021. Physicians provided data on patients’ PsA severity and symptoms, and their satisfaction with current treatment. Patients provided information on patient-reported outcomes and treatment satisfaction. Linear regression analyses assessed the impact of disease severity, fatigue, enthesitis, dactylitis, inflammatory back pain, sacroiliitis and tender and swollen joints on EuroQoL 5-Dimension 5-Level Quality of Life Survey (EQ-5D-5L), the Work Productivity and Activity Impairment Questionnaire (WPAI) and Psoriatic Arthritis Impact of Disease (PsAID12). Logistic regressions analysed satisfaction and EQ-5D-5L domains.

RESULTS: Data were collected for 2,113 patients from 520 physicians. Tender joints were associated with a 0.61-point increase in PsAID12 (p<0.001), a 3.2-fold increase in the odds of affected mobility (p<0.001), and a 2.4-fold increase in the odds of experiencing pain/discomfort (p<0.001). Enthesitis was associated with a 0.93-point increase in PsAID12 (p=0.003). Fatigue was associated with a 9.6 percentage point (pp) increase in activity impairment (p<0.001) and 1.0-point increase in PsAID12 (p<0.001). EQ-5D-5L decreased by 0.064 for moderate/severe disease relative to mild (p<0.001), PsAID12 increased by 0.94 (p<0.001) and activity impairment increased by 11pp (p<0.001); odds of physician-reported treatment satisfaction decreased by 69% (p<0.001). Fatigue was associated with decreased odds of patient and physician treatment satisfaction by 78% (p<0.001) and 53% (p=0.015) respectively.

CONCLUSIONS: Individual PsA clinical features had a significant impact on patients’ HRQoL, daily activity, and treatment satisfaction in both physicians and patients; highlighting the importance of effective symptom management to improve patients’ HRQoL.