Using High Quality Open Data to Find Long Term Results in an Continuously Enrolled Population, an Example in BPH
Author(s)
Periyanayagam U, Wei Y
Komodo Health, San Francisco, CA, USA
Presentation Documents
OBJECTIVES: Research studies have traditionally focused on continuously enrolled (CE) patients, however, in therapeutic areas that have a long time-to-event this leads to limited outcomes data. The goal of this study is to describe outcomes in CE patients with closed/open follow-up periods.
METHODS: This retrospective cohort study was performed on patients with medication therapy for BPH from1/1/2017 to 6/30/2021 over 40 years old and no history of malignancy. Three cohorts were created with 1 year, 2 year or 3 years of continuous enrollment after the event. Rates and time to surgery were calculated during the CE window and for all time. Demographics including age, region, year, Charlson Comorbidity Index and previous medications were calculated. Rates and time to surgery was compared between the different cohorts.
RESULTS: Cohorts with 586,443 patients(1 year CE), 382,859 patients(2 years CE) and 246,959 patients(3 year CE) were followed. Similar percentages of patients received surgical treatment during the first year in 1, 2 and 3 years CE: 21,103 (3.6%,), 2,746 (3.3%) and 1, 7,927 (3.2%) respectively. Within two years, 5.0% (2 years CE) and 4.8% (3 years CE) received surgery; within three years, 6.2% of patients (3 years CE) received surgery. The all time treated population and mean (SD) time to event was 7.5% and 531 (479) days (1 year CE), 7.8% and 592 (494) days (2 years CE), and 8.1% and 650 (521) days (3 years CE).
CONCLUSIONS: Within this dataset, similar surgical rates were seen in each CE cohort, however, the largest volume of events was seen in the open time frame. The shortest CE period had the largest volume of surgical treatments and a similar percentage of surgeries compared to longer periods.
Conference/Value in Health Info
Value in Health, Volume 26, Issue 6, S2 (June 2023)
Code
EPH197
Disease
Surgery