Identification of Patients With Obesity, Based on Their Comorbidities

Author(s)

Seitz L1, John N2, Kossack N2, Häckl D3, Müller-Wieland D4, Verket M4
1Novo Nordisk Pharma GmbH, Mainz, Germany, 2WIG2 GmbH, Leipzig, SN, Germany, 3University of Leipzig, Health Economics and Management, Leipzig, SN, Germany, 4University Hospital Aachen, Aachen, NRW, Germany

Presentation Documents

OBJECTIVES: Obesity is frequently undercoded in health care or claims data sets. The aim of this project was to develop a predictive model based on comorbidities, identifying patients at high risk of obesity, as a solution to overcome the limited documentation in claims data sets.

METHODS: In a comprehensive literature search, comorbidities associated with obesity were identified. Additionally, associated comorbidities were identified in claims data (n=3,244,611) from the statutory health insurance system in Germany. From these data, a predictive model was developed, and then validated by data from the UK biobank (n=502,384). In contrast to German claims data, where obesity is documented only using the ICD-10 diagnosis code E66, in the UK biobank diagnosis could be validated in addition by documented body mass index (BMI) of >30 kg/m².

RESULTS: Using multiple comorbidities, the model showed good predictive performance in identifying patients living with obesity in German claims data, with an area under curve (AUC) of 83%. The validation based on UK biobank data showed a slightly decreasing predictive power (AUC: 76%), however, it confirmed that the model can be transferred to other databases. An enhanced validation using BMI to identify obesity revealed a further decrease in predictive performance (AUC: 69%).

CONCLUSIONS: The results indicate the robust predictive power of identifying obesity in claims data sets using this model. This validated model may be used to analyze obesity-related healthcare efforts in different secondary data sets. Furthermore, the lower predictive power of detecting patients with a BMI >30 kg/m², suggests that patients with obesity who have not yet been diagnosed as such by physicians, suffer from fewer comorbidities and are therefore more difficult to identify using such models.

Conference/Value in Health Info

2024-11, ISPOR Europe 2024, Barcelona, Spain

Value in Health, Volume 27, Issue 12, S2 (December 2024)

Code

MSR162

Topic

Methodological & Statistical Research

Topic Subcategory

Artificial Intelligence, Machine Learning, Predictive Analytics

Disease

Diabetes/Endocrine/Metabolic Disorders (including obesity), No Additional Disease & Conditions/Specialized Treatment Areas

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