OBJECTIVES: Myocardial infarction (MI), commonly known as a heart attack, significantly impacts patients' health and well-being. Medication adherence is crucial for successful post-MI management. Medication Therapy Management (MTM) interventions aim to optimize medication use and improve patient outcomes. However, the specific effects of MTM interventions on PRO in MI patients remain unclear. This study aimed to investigate the effectiveness of MTM interventions in improving clinical and quality-of-life outcomes among patients with MI.

METHODS: A two-group, comparative study design was employed. Patients admitted for MI were recruited and assigned to either an MTM intervention group or a control group receiving standard care. The Seattle Angina Questionnaire(SAQ) questionnaire, a well-validated PRO measure, was administered to both groups upon hospital admission (baseline) and one month after discharge. Analysis of Covariance (ANCOVA) was used to compare changes in SQA scores between the MTM and control groups, adjusting for baseline SQA scores.

RESULTS: Forty-two patients were enrolled, eight in the MTM group and thirty-four in the control group. The descriptive analyses showed that patients in the MTM group demonstrated noticeable improvement in all SAQ domain scores compared to the control group after one month. However, the results from ANCOVA revealed that only one SAQ domain(Physical Function) had a statistically significant difference (p = 0.031) in the change between groups.

CONCLUSIONS: This study provides preliminary evidence for the potential benefits of MTM interventions in improving physical functioning, a key aspect of SAQ, in MI patients. Further research is warranted to confirm these findings, explore the impact on other SAQ domains, and investigate the long-term effects and cost-effectiveness of MTM in this patient population. Such knowledge can inform the development of comprehensive strategies for optimizing medication management and improving the quality of life for MI patients.