OBJECTIVES: PM is often associated with precision therapeutics, but recently, the use of PM and precision approaches, such as genetic-testing, are increasingly becoming more holistic, covering other aspects of patient care, including disease prevention and patient management/care. Study explores how applications of precision approaches (PH/PM) could deliver at population level, mitigating rising healthcare expenditures, particularly in the face of an ageing population with an increase in chronic disease prevalence and the risk of future pandemics.

METHODS: We conducted targeted literature review on the definition of PH/PM and its value by assessing nine dimensions of value along the patient care pathway (e.g., improved clinical effectiveness, reduced adverse events, efficiency in resources allocation etc.), link with population health and existing PH/PM approaches across four disease areas in selected countries between 2015 and 2022. Selection of disease areas was based on their contribution to disease burden in Europe – cancer (breast and lung), CVD – familial hypercholesterolemia (FH), type 1 DM and COVID-19. Besides assessing the value of PH/PM, we analysed the level of adoption of PH /PM approaches across selected countries. We conducted an external interview program (experts and PAGs) to validate our research.

RESULTS: Study shows a significant value of PH/PM in cancer (diagnosis and treatment), in FH (screening and diagnosis), in type 1 DM (patient management/care) and in COVID-19 (prevention). We found notable differences in the adoption of recent PH/PM innovations in cancer diagnosis and treatment; for FH we found low to medium-range utilisation rates of genetic-testing for diagnosis; there are significant variations in the target populations eligible for CGM for type 1 DM patients access; genomic surveillance of SARS-CoV-2 varied by country, potentially influencing prevention strategies.

CONCLUSIONS: PH/PM has the potential to greatly improve population health outcomes. For PH/PM to deliver for European patients, several key policy recommendations must be implemented.