Cost-Effectiveness of a Genomic Profiling Test for HRD Determination in Ovarian Cancer Into the Current Clinical Practice for Platinum-Sensitive Patients With Advanced Ovarian Cancer in Greece

Author(s)

Zisis K1, Nomikos N2, Naoum P1, Agorastos I1, Athanasakis K1
1University of West Attica, Athens, Attica, Greece, 2University of West Attica, Athens, A1, Greece

OBJECTIVES: This study aims to assess the cost-effectiveness of integrating genomic profiling for determining Homologous Recombination Deficiency (HRD) status in advanced ovarian cancer into the current clinical practice in Greece.

METHODS: A comprehensive cost-effectiveness analysis was conducted to evaluate the integration of genomic profiling into the clinical practice for platinum-sensitive patients with advanced ovarian cancer in Greece, compared to the current standard of care. A decision-analytic model was developed to compare the costs, clinical outcomes, and cost-effectiveness of the two strategies. Data on costs, clinical parameters, utilities and resource utilization were obtained from relevant literature sources. The primary outcome was measured in terms of cost per quality-adjusted progression-free survival (QA-PFS). Additionally, a scenario analysis was performed to estimate the cost per quality-adjusted life year (QALY), providing further insights into the economic implications of the intervention. Discounting was applied to both costs and outcomes using a discount rate of 3% per annum.

RESULTS: The utilization of genomic profiling testing was associated with an additional cost of €28,417 and to an increase of 0.608 in quality-adjusted progression-free survival (QA-PFS), resulting in a incremental cost-effectiveness ratio (ICER) of €46,736 per QA-PFS. Furthermore, the cost per QALY was estimated to be €28,138, indicating that the intervention is cost-effective. Sensitivity analysis demonstrated the robustness of the main findings.

CONCLUSIONS: The integration of genomic profiling for determining HRD status in ovarian cancer is deemed cost-effective and can result in long-term savings. These findings support the implementation of this strategy as part of the standard clinical practice in Greece.

Conference/Value in Health Info

2023-11, ISPOR Europe 2023, Copenhagen, Denmark

Value in Health, Volume 26, Issue 11, S2 (December 2023)

Code

EE232

Topic

Economic Evaluation

Topic Subcategory

Cost-comparison, Effectiveness, Utility, Benefit Analysis

Disease

No Additional Disease & Conditions/Specialized Treatment Areas, Oncology

Explore Related HEOR by Topic


Your browser is out-of-date

ISPOR recommends that you update your browser for more security, speed and the best experience on ispor.org. Update my browser now

×