Epidemiology and Patient Characteristics of Pemphigus Vulgaris in Italy Based on Administrative Database
Author(s)
De Ruyck F1, Degli Esposti L2, Giacomini E3, Leogrande M2, Wittlin B1, Iannazzo S1, Agalarov Y1, Blein C4
1argenx BVBA, Ghent, Belgium, 2CliCon S.r.l. Società Benefit Health, Economics & Outcomes Research, Bologna, BO, Italy, 3CliCon S.r.l. Società Benefit Health, Economics & Outcomes Research, Bologna, Italy, 4argenx BVBA, Zwijnaarde, Belgium
OBJECTIVES: Pemphigus diseases are life-threatening, chronic, autoimmune blistering diseases (AIBDs). This research aims to explore pemphigus vulgaris (PV) epidemiology in Italy, using real world database.
METHODS: This retrospective cohort study included patients with PV in administrative database Local Health Units from January 2010 to December 2020. Eligible patients require at least one hospitalization discharge diagnosis at primary or secondary level for pemphigus (ICD-9-CM: 694.4); an exemption code for PV (code: RL0030) and a continuous enrolment for at least 12 months. We considered the index date as the first match with inclusion criteria.
Prevalence and Incidence were calculated on an integrated database including both in- and out-patients, geographically distributed and with demographic characteristics representative of the Italian population, covering 6 million health-assisted subjects.RESULTS: From the claims database, we identified 537 patients with an exemption code for PV.
Among 28% (n=149) had at least one hospitalization discharge diagnosis for PV and 72% (n=388) had no hospitalization. In the first sub-cohort, 44.3% were men, mean (SD) age at index date was 55.8 (13.0), mean (SD) years of follow-up were 5.7 (2.8) , and the mean (SD) CCI index was 0.7 (0.9) . In 2020 prevalence and incidence were respectively 22 and 2 cases per million. The incidence is quite stable over time and prevalence increases of +38%. In the second sub-cohort 38,7% were men, mean (SD) age at index date was 56.1 (13.7), mean (SD) years of follow-up were 5.5 (2.6) and the mean (SD) CCI index was 0.6 (0.8) . In 2020 prevalence and incidence were respectively 41 and 4 cases per million. The prevalence increases with 32% over the time.CONCLUSIONS: In 2020, the overall incidence of Pemphigus vulgaris is estimated at 6 cases per million with a predominance in women. The findings are matching the previous literature (Micali et al., 1998).
Conference/Value in Health Info
Value in Health, Volume 26, Issue 11, S2 (December 2023)
Code
EPH39
Topic
Study Approaches
Disease
Rare & Orphan Diseases, Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)