Impact of Phase Angle in Quality of Life and Mortality in Male With Head and Neck Cancer
Author(s)
Gutiérrez-Rodríguez LX1, Sat-Muñoz D2, Martínez-Herrera B3, González Rodríguez J4, Mireles-Ramírez M5, Trujillo-Hernández B6, Quiroga-Morales LA7, Alcaráz-Wong AA8, Dávalos-Cobian C8, Solórzano-Meléndez A9, Flores-Carlos JD10, Rubio Jurado B9, Salazar-Páramo M11, Gómez-Sánchez E12, Carrillo-Nuñez GG11, Nava-Zavala AH13, Balderas-Peña LMA14
1Universidad de Guadalajara. Centro Universitario del Sur, Ciudad Guzmán, JA, Mexico, 2Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, JAL, Mexico, 3Hospital General de Zona No. 2 "Dr. Francisco Padrón Puyou", Colima, Mexico, 4Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Zapopan, JAL, Mexico, 5Instituto Mexicano del Seguro Social. UMAE Hospital de Especialidades. Centro Médico Nacional de Occidente, Guadalajara , JAL, Mexico, 6Universidad de Colima, Colima, JA, Mexico, 7Universidad Autónoma de Guadalajara, Zapopan, JA, Mexico, 8Instituto Mexicano del Seguro Social. UMAE Hospital de Especialidades. Centro Médico Nacional de Occidente, Guadalajara, JA, Mexico, 9UMAE Hospital de Especialidades Centro Médico Nacional de Occidente IMSS, Guadalajara, Jalisco, JA, Mexico, 10UMAE Hospital de Especialidades Centro Médico Nacional de Occidente., Guadalajara, Jalisco, JA, Mexico, 11Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, JA, Mexico, 12Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico, 13Instituto Mexicano del Seguro Social, Órgano de Operación Administrativa Desconcentrada Jalisco, Guadalajara, JA, Mexico, 14Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, JAL, Mexico
Presentation Documents
OBJECTIVES: To determine the role of phase angle in survival and QoL in a men population with H&N cancer
METHODS: The selected subjects were divided into two groups: men with PA < 4.47° and men with PA ≥ 4.47°. Both of them were followed up for at least two years. We evaluated survival and quality of life
RESULTS: Sample studied of 107 patients with a mean age of 65.4 years. Patients with a PA ≥ 4.47 had an ≈30% higher probability of survival at two years with a better quality of life compared to patients with a PA< 4.47°. Statistical differences were found in the functional and symptom scales, with lower functional scores and higher symptom scores in patients with low PA. In QLQ-C30 the observed differences were Global Health State/QoL (mean 63 versus 76; p=0.006), physical (64.9 versus 86.9, p=0.000) and role (64.5 versus 82.7, p=0.008) functioning, fatigue, pain and loss of appetite, in QLQ H&N35: deglutition, senses problems, troubles with eating social, less sexuality, opening mouth, dry mouth, sticky saliva, felt ill, pain killer, nutritional supplements and feeding tube, between PA <4.47 and ≥4.47 PA all with p<0.05. Median survival was 21.8 months for those with PA <4.47° versus 34.3 months for those with PA ≥ 4.47° (p<0.006). The percentage of deceased subjects (62.5%; p=0.005), with high mortality rates in patients with PA <4.47º. In patients with PA ≥4.47 the mortality rate was 33.3%.
CONCLUSIONS: Phase angle was the most crucial predictor of improved QoL, survival and a risk factor for death in male with H&NC.
Conference/Value in Health Info
Value in Health, Volume 25, Issue 12S (December 2022)
Code
CO106
Topic
Clinical Outcomes, Patient-Centered Research
Topic Subcategory
Clinical Outcomes Assessment, Patient-reported Outcomes & Quality of Life Outcomes, Relating Intermediate to Long-term Outcomes
Disease
SDC: Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal), SDC: Oncology, STA: Nutrition