OBJECTIVES: A single-tablet, once-daily antiretroviral regimen constitutes current first-line HIV therapies. Patient non-compliance may risk the emergence of drug resistant virus. Alternative treatments, e.g., a long-acting injectable (LAI) therapy have been developed to reduce dosing frequency and potentially improve long-term adherence. This study assessed patients’ reported satisfaction with and unmet needs of their current ART regimens as well as their perspectives towards LAI. Physicians’ satisfaction with current HIV treatments and their perspectives towards the injectable treatment were also explored.

METHODS: An online survey was conducted between October-December 2021 among 50 people living with HIV (PLWH) (aged ≥20 years) and 30 physicians with HIV treatment experience in Taiwan. Questionnaire items pertained to PLWH’s and physicians’ satisfaction with current HIV treatment and their perspectives towards LAI, and PLWH’s mental burden.

RESULTS: 58% of PLWH felt totally satisfied with their current oral daily ART. PLWH’s lack of satisfaction was due to the need to take HIV therapy daily (52%) and because treatment reminded them of having HIV (50%) 32% reported avoiding others when taking their medicine. The majority felt burdened: 92% hid their condition from others, felt ashamed of having HIV (72%), and the daily reminder of HIV as they complied with treatment (70%). PLWH perceived LAI as a mean to reduce the stress of missed doses (100%), life restrictions (90%) and risks of disclosure (86%). Among physicians, 30% perceived a need for a HIV treatment to improve the social impact of living with HIV and 67% were excited for LAI. Physicians projected that approximately 26% of their current patients with HIV would prefer LAI treatment if available and would recommend LAI treatment to 31% of their current patients.

CONCLUSIONS: The lack of satisfaction towards current oral once-daily and the perceived PLWH’s mental burden may potentially be addressed by the adoption of a LAI HIV treatment option.