Population Reference Costs for Average Total Annual Care in the UK National Health Service for 11 Common Diseases or Conditions vs. Matched Controls
Author(s)
Sarah E. Holden, PhD, Kendra-Jean Nwamadi, MBBCh, Ben Heywood, MSc, Christopher Morgan, PhD, Sara Jenkins-Jones, MSc, Aron Buxton, BSc, Craig John Currie, BSc, PhD.
Human Data Sciences, Cardiff, United Kingdom.
Human Data Sciences, Cardiff, United Kingdom.
OBJECTIVES: Our objective was to provide NHS reference costs for 11 common conditions.
METHODS: People were selected from Clinical Practice Research Datalink (CPRD) Aurum, linked to Hospital Episode Statistics Admitted Patient Care and Outpatient datasets. Incident cases were selected if their first record for one of the following conditions was recorded after 1st January 2009 (inclusive) and at least 180 days after primary care practice registration: fractured neck of femur (NOF), stroke, breast cancer, prostate cancer, eating disorders, type 2 diabetes (T2D), osteoporosis, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, atopic dermatitis and attention deficit hyperactivity disorder (ADHD). The annualised cost of all-cause primary care contacts, prescriptions, outpatient attendances and hospital admissions was compared with non-exposed controls matched (1:1) on age, sex and general practice. Data were analysed through Livingstone, a healthcare data analytics platform.
RESULTS: Cohort size varied from 13,743 for eating disorders to 987,758 for atopic dermatitis. Mean follow-up for cases varied from 2.5 years for fractured NOF to 5.0 years for atopic dermatitis. Mean age was lowest in the ADHD cohort (15.6 years) and highest in the cohort with fractured NOF (79.8 years). The percentage of females was highest in the breast cancer cohort (98.0%) and lowest (excluding prostate cancer) in the ADHD cohort (25.1%). Mean total healthcare costs per person-year for cases versus controls were: atopic dermatitis, £1,248 vs £985 (x1.3); ADHD, £1,436 vs £419 (x3.4); T2D, £2,760 vs £1,634 (x1.7); eating disorders, £2,875 vs £825 (x3.5); osteoporosis, £4,554 vs £2,411 (x1.9); COPD, £4,567 vs £2,065 (x2.2); rheumatoid arthritis, £4,615 vs £1,944 (x2.4); breast cancer, £4,683 vs £1,814 (x2.6); prostate cancer, £4,751 vs £2,594 (x1.8); stroke, £6,720 vs £2,547 (x2.6); fractured NOF, £8,271 vs £3,077 (x2.7).
CONCLUSIONS: These analyses provide valuable information on the relative UK healthcare financial burden associated with a range of common conditions.
METHODS: People were selected from Clinical Practice Research Datalink (CPRD) Aurum, linked to Hospital Episode Statistics Admitted Patient Care and Outpatient datasets. Incident cases were selected if their first record for one of the following conditions was recorded after 1st January 2009 (inclusive) and at least 180 days after primary care practice registration: fractured neck of femur (NOF), stroke, breast cancer, prostate cancer, eating disorders, type 2 diabetes (T2D), osteoporosis, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, atopic dermatitis and attention deficit hyperactivity disorder (ADHD). The annualised cost of all-cause primary care contacts, prescriptions, outpatient attendances and hospital admissions was compared with non-exposed controls matched (1:1) on age, sex and general practice. Data were analysed through Livingstone, a healthcare data analytics platform.
RESULTS: Cohort size varied from 13,743 for eating disorders to 987,758 for atopic dermatitis. Mean follow-up for cases varied from 2.5 years for fractured NOF to 5.0 years for atopic dermatitis. Mean age was lowest in the ADHD cohort (15.6 years) and highest in the cohort with fractured NOF (79.8 years). The percentage of females was highest in the breast cancer cohort (98.0%) and lowest (excluding prostate cancer) in the ADHD cohort (25.1%). Mean total healthcare costs per person-year for cases versus controls were: atopic dermatitis, £1,248 vs £985 (x1.3); ADHD, £1,436 vs £419 (x3.4); T2D, £2,760 vs £1,634 (x1.7); eating disorders, £2,875 vs £825 (x3.5); osteoporosis, £4,554 vs £2,411 (x1.9); COPD, £4,567 vs £2,065 (x2.2); rheumatoid arthritis, £4,615 vs £1,944 (x2.4); breast cancer, £4,683 vs £1,814 (x2.6); prostate cancer, £4,751 vs £2,594 (x1.8); stroke, £6,720 vs £2,547 (x2.6); fractured NOF, £8,271 vs £3,077 (x2.7).
CONCLUSIONS: These analyses provide valuable information on the relative UK healthcare financial burden associated with a range of common conditions.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
EE611
Topic
Economic Evaluation
Topic Subcategory
Cost/Cost of Illness/Resource Use Studies