Significant Burden of Chronic Obstructive Pulmonary Disease (COPD) on Health Status and Well-Being Persists Among Patients Experiencing One Severe or Two or More Moderate Exacerbations of COPD (ECOPD) and Their Caregivers (CGs)
Author(s)
Denise Boudreau, PhD1, Johannes Ammann, PhD2, Joanna DeCourcy, BSc3, Jacob Devine, MA1, Paul Hernandez, MDCM, FRCPC4, Claudio Micheletto, MD5, Jennifer Quint, MSc, MBBS, PhD6, Katerina Samara, MSc, PhD, MD2, Tonya Winders, MBA7, Per-Olof Thuresson, MSc2.
1Genentech, Inc., South San Francisco, CA, USA, 2F. Hoffmann-La Roche, Ltd, Basel, Switzerland, 3Adelphi Real World, Bollington, United Kingdom, 4Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, NS, Canada, 5University of Verona, Verona, Italy, 6Imperial College London, London, United Kingdom, 7Global Allergy and Airways Patient Platform, Vienna, VA, USA.
1Genentech, Inc., South San Francisco, CA, USA, 2F. Hoffmann-La Roche, Ltd, Basel, Switzerland, 3Adelphi Real World, Bollington, United Kingdom, 4Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, NS, Canada, 5University of Verona, Verona, Italy, 6Imperial College London, London, United Kingdom, 7Global Allergy and Airways Patient Platform, Vienna, VA, USA.
OBJECTIVES: Quantify the burden of COPD on patients and CGs.
METHODS: Cross-sectional design using electronic health records and survey data. Patients and their CG, were invited by their physicians, if patients met criteria of ≥40 years of age, COPD, 1-year history of ≥2 moderate or ≥1 severe ECOPD, using ≥1 inhaled maintenance medication, FEV1 ≥20% to <80%, no other significant pulmonary disease, and residing in Canada, Italy, or the United Kingdom (UK). Target sample size was 150 patient/CG dyads with enrichment of severe ECOPD. Data were summarized overall and by severity.
RESULTS: The study included 155 patients and 152 CGs (21% Canada, 41% Italy, 39% UK). Mean age 69 in patients, 59 in CGs; 29% of patients and 79% of CGs were female, 74% in urban areas, 18% of patients and 35% of CGs were employed, and 70% of CGs were the patient’s partner/spouse and 22% their children. 45% of patients had ≥1 severe ECOPD and 55% ≥2 moderate ECOPD. Calculated among all patients and using country-specific value sets, mean EQ-5D-5L was 0.684 Canada, 0.674 Italy, and 0.591 UK. The EuroQoL Health and Wellbeing short form yielded a mean UK index score of 0.608. Mean overall work impairment was 34% due to COPD in patients and 34% due to caregiving in CGs. 61% of patients scored high/very high (>20) on the Chronic Airway Assessment Test. 24% of CGs scored high burden (≥20) and 32% mild/moderate burden (10-19) on the Zarit-Burden Interview. Mean caregiving time was 4-5 hours/day and top tasks were managing the home (29%), activities of daily living (23%) and emotional support (15%). Burden measures were similar across ECOPD severity.
CONCLUSIONS: This study captured significant burden among patients with a 1-year history of one severe or ≥2 moderate ECOPD and their CGs, highlighting measures underreported in the literature.
METHODS: Cross-sectional design using electronic health records and survey data. Patients and their CG, were invited by their physicians, if patients met criteria of ≥40 years of age, COPD, 1-year history of ≥2 moderate or ≥1 severe ECOPD, using ≥1 inhaled maintenance medication, FEV1 ≥20% to <80%, no other significant pulmonary disease, and residing in Canada, Italy, or the United Kingdom (UK). Target sample size was 150 patient/CG dyads with enrichment of severe ECOPD. Data were summarized overall and by severity.
RESULTS: The study included 155 patients and 152 CGs (21% Canada, 41% Italy, 39% UK). Mean age 69 in patients, 59 in CGs; 29% of patients and 79% of CGs were female, 74% in urban areas, 18% of patients and 35% of CGs were employed, and 70% of CGs were the patient’s partner/spouse and 22% their children. 45% of patients had ≥1 severe ECOPD and 55% ≥2 moderate ECOPD. Calculated among all patients and using country-specific value sets, mean EQ-5D-5L was 0.684 Canada, 0.674 Italy, and 0.591 UK. The EuroQoL Health and Wellbeing short form yielded a mean UK index score of 0.608. Mean overall work impairment was 34% due to COPD in patients and 34% due to caregiving in CGs. 61% of patients scored high/very high (>20) on the Chronic Airway Assessment Test. 24% of CGs scored high burden (≥20) and 32% mild/moderate burden (10-19) on the Zarit-Burden Interview. Mean caregiving time was 4-5 hours/day and top tasks were managing the home (29%), activities of daily living (23%) and emotional support (15%). Burden measures were similar across ECOPD severity.
CONCLUSIONS: This study captured significant burden among patients with a 1-year history of one severe or ≥2 moderate ECOPD and their CGs, highlighting measures underreported in the literature.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
PCR216
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities, Patient-reported Outcomes & Quality of Life Outcomes
Disease
No Additional Disease & Conditions/Specialized Treatment Areas, Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory)