Multimorbidity and Health-Related Quality of Life Among Adult Population in the United States
Author(s)
Monira Alwhaibi, PhD1, Bander Balkhi, PharmD, PhD2.
1Associate Professor, King Saud University, Riyadh, Saudi Arabia, 2King Saud University, Riyadh, Saudi Arabia.
1Associate Professor, King Saud University, Riyadh, Saudi Arabia, 2King Saud University, Riyadh, Saudi Arabia.
OBJECTIVES: This study aimed to evaluate the relationship between Multimorbidity and adults' Health-Related Quality of Life (HRQoL).
METHODS: A cross-sectional study among adults aged 18 to 64 years old was conducted. Data from the Medical Expenditure Panel Survey was used in this study. The primary study outcome was the HRQoL; it was evaluated using the 12-item Short Form Health Survey (SF-12). Descriptive analysis was used to describe the characteristics of the study sample. The adjusted relationship between Multimorbidity and HRQoL was assessed using the multivariable linear regression after other factors were adjusted in the regression analysis.
RESULTS: The study sample consists of 30,827 adults. Multimorbidity was prevalent among 23.4% of adults. It was higher among women, unemployed, poor, and physically inactive adults. Adults with multimorbidity had a lower mean HRQoL score than those without multimorbidity (Physical health = 46.06 vs. 53.29, Mental health = 47.62 vs. 52.37). Results from the adjusted linear regression model found that adults with multimorbidity have a significantly lower HRQoL in both the physical domain (β = -2.658, p-value<0.0001), and the mental domain (β = -3.119, p-value<0.0001).
CONCLUSIONS: This study evaluated the relationship between multimorbidity and adults' HRQoL. The findings revealed a significant negative impact of multimorbidity on the physical and mental domains of HRQoL in adults. These results have important implications for public health, policy, and clinical practice, highlighting the need for interventions to alleviate the burden of multimorbidity and improve adults' quality of life. Further research is needed to determine the specific types of multimorbidity that strongly impact HRQoL, which will guide future interventions and improve patient outcomes.
METHODS: A cross-sectional study among adults aged 18 to 64 years old was conducted. Data from the Medical Expenditure Panel Survey was used in this study. The primary study outcome was the HRQoL; it was evaluated using the 12-item Short Form Health Survey (SF-12). Descriptive analysis was used to describe the characteristics of the study sample. The adjusted relationship between Multimorbidity and HRQoL was assessed using the multivariable linear regression after other factors were adjusted in the regression analysis.
RESULTS: The study sample consists of 30,827 adults. Multimorbidity was prevalent among 23.4% of adults. It was higher among women, unemployed, poor, and physically inactive adults. Adults with multimorbidity had a lower mean HRQoL score than those without multimorbidity (Physical health = 46.06 vs. 53.29, Mental health = 47.62 vs. 52.37). Results from the adjusted linear regression model found that adults with multimorbidity have a significantly lower HRQoL in both the physical domain (β = -2.658, p-value<0.0001), and the mental domain (β = -3.119, p-value<0.0001).
CONCLUSIONS: This study evaluated the relationship between multimorbidity and adults' HRQoL. The findings revealed a significant negative impact of multimorbidity on the physical and mental domains of HRQoL in adults. These results have important implications for public health, policy, and clinical practice, highlighting the need for interventions to alleviate the burden of multimorbidity and improve adults' quality of life. Further research is needed to determine the specific types of multimorbidity that strongly impact HRQoL, which will guide future interventions and improve patient outcomes.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
CO167
Topic
Clinical Outcomes, Epidemiology & Public Health, Patient-Centered Research
Topic Subcategory
Clinical Outcomes Assessment, Clinician Reported Outcomes
Disease
No Additional Disease & Conditions/Specialized Treatment Areas