Pertussis Vaccination and Test Rates in Germany by Asthma-COPD Comorbidity Status: A Healthcare Claims Data Analysis in Germany
Author(s)
Denis Macina, PhD1, Melanie Fomenko, B.Sc.2, Jonas Krampe, PhD2, Céline Vetter, PhD3.
1Sanofi, Lyon, France, 2Gesundheitsforen, Leipzig, Germany, 3IQVIA Commercial GmbH & Co. OHG, Frankfurt a.M., Germany.
1Sanofi, Lyon, France, 2Gesundheitsforen, Leipzig, Germany, 3IQVIA Commercial GmbH & Co. OHG, Frankfurt a.M., Germany.
OBJECTIVES: To quantify pertussis vaccination rates among adults in Germany.
METHODS: This retrospective analysis used a representative sample of German claims data (2013-2019) for adult patients. We report overall vaccination rates and compare incidence rate ratios (IRRs) across age groups and respiratory subgroups (asthma, chronic obstructive pulmonary disease [COPD], or neither).
RESULTS: Among 2.5 million SHI-insured patients with ≥2 years of enrollment, the standardized pertussis vaccination rate was 47.7 per 1,000 person-years (PY). Overall, 21.8% of patients received at least one pertussis vaccination during the study period. Vaccination rates were significantly higher in asthma patients (56.3/1,000 PY; IRR = 1.19, 95% CI: 1.18-1.21, p < 0.001) compared to those without asthma or COPD. In contrast, COPD patients had similar rates to those without respiratory conditions (47.2 vs. 46.8/1,000 PY; IRR = 0.99, 95% CI: 0.98-1.00, p = 0.16). Among patients aged ≥65 years, both asthma and COPD subgroups were less likely to be vaccinated than those aged 18-44 (asthma: IRR = 0.88, 95% CI: 0.85-0.91; COPD: IRR = 0.83, 95% CI: 0.79-0.88; both p < 0.001).
CONCLUSIONS: Despite their elevated risk of pertussis complications, older adults with asthma or COPD are less likely to receive pertussis vaccination. These findings highlight a gap in preventive care for high-risk populations.
METHODS: This retrospective analysis used a representative sample of German claims data (2013-2019) for adult patients. We report overall vaccination rates and compare incidence rate ratios (IRRs) across age groups and respiratory subgroups (asthma, chronic obstructive pulmonary disease [COPD], or neither).
RESULTS: Among 2.5 million SHI-insured patients with ≥2 years of enrollment, the standardized pertussis vaccination rate was 47.7 per 1,000 person-years (PY). Overall, 21.8% of patients received at least one pertussis vaccination during the study period. Vaccination rates were significantly higher in asthma patients (56.3/1,000 PY; IRR = 1.19, 95% CI: 1.18-1.21, p < 0.001) compared to those without asthma or COPD. In contrast, COPD patients had similar rates to those without respiratory conditions (47.2 vs. 46.8/1,000 PY; IRR = 0.99, 95% CI: 0.98-1.00, p = 0.16). Among patients aged ≥65 years, both asthma and COPD subgroups were less likely to be vaccinated than those aged 18-44 (asthma: IRR = 0.88, 95% CI: 0.85-0.91; COPD: IRR = 0.83, 95% CI: 0.79-0.88; both p < 0.001).
CONCLUSIONS: Despite their elevated risk of pertussis complications, older adults with asthma or COPD are less likely to receive pertussis vaccination. These findings highlight a gap in preventive care for high-risk populations.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
EPH178
Topic
Epidemiology & Public Health
Topic Subcategory
Public Health
Disease
Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory), Vaccines