Medication Adherence and Its Predictors in Rheumatoid Arthritis Patients
Author(s)
NIHARIKA BINDAL, PharmD1, Shivangi Suman, PharmD2, Kartik Verma, PharmD2.
1Student, MM College of Pharmacy, Maharishi Markandeshwar (Deemed To Be) University, ambala, India, 2MM College of Pharmacy, Maharishi Markandeshwar (Deemed To Be) University, Ambala, India.
1Student, MM College of Pharmacy, Maharishi Markandeshwar (Deemed To Be) University, ambala, India, 2MM College of Pharmacy, Maharishi Markandeshwar (Deemed To Be) University, Ambala, India.
OBJECTIVES: To assess the factors affecting poor adherence in Rheumatoid arthritis patients and the quality of life in Rheumatoid arthritis patients.
METHODS: Medication adherence in RA patients is investigated in this paper together with its clinical, laboratory, and socioeconomic aspects as well as how it affects disease severity and quality of life.A cross-sectional, observational study of 110 RA patients was undertaken at MMIMSR, Mullana. The sociodemographic profiles, MMAS-4, WHOQOL-BREF & Modified Kuppuswamy scale were used to collect data. DAS-28 values assessed disease activity. SPSS was used for Pearson correlation, logistic regression, and t-tests.
RESULTS: Gender disparities were found in sociodemographic, laboratory, and adherence characteristics. Female patients had more anaemia, CRP(0.03), ESR(0.03), and Anti-CCP positive(0.03), suggesting disease severity. Social class, education, and quality of life strongly correlated with medication adherence, which was poor. Adherence increased QoL and decreased illness activity.
CONCLUSIONS: Women with more severe disease activity that is, higher DAS-28 scores, increased CRP and ESR, anaemia, and positive anti-CCP antibodies had poorer treatment adherence, according this study. Poor adherence was associated with increased diastolic blood pressure, anaemia, elevated CRP and ESR, and notable anti-CCP positivity in MMAS-4. Our MMAS-4 findings revealed that less adherent individuals had higher rates of deliberate dose skipping and forgetfulness. Many female patients had lower socioeconomic level, according to Kuppuswamy scoring, which was linked to poor adherence and worse WHOQOL-BREF quality of life ratings across all categories. Structural and psychological obstacles must be removed if long-term success and equitable treatment for every patient are to occur. Studies reveal that gender-sensitive, all-encompassing treatment plans addressing clinical and socioeconomic factors of health enhance RA patient adherence and outcomes.
METHODS: Medication adherence in RA patients is investigated in this paper together with its clinical, laboratory, and socioeconomic aspects as well as how it affects disease severity and quality of life.A cross-sectional, observational study of 110 RA patients was undertaken at MMIMSR, Mullana. The sociodemographic profiles, MMAS-4, WHOQOL-BREF & Modified Kuppuswamy scale were used to collect data. DAS-28 values assessed disease activity. SPSS was used for Pearson correlation, logistic regression, and t-tests.
RESULTS: Gender disparities were found in sociodemographic, laboratory, and adherence characteristics. Female patients had more anaemia, CRP(0.03), ESR(0.03), and Anti-CCP positive(0.03), suggesting disease severity. Social class, education, and quality of life strongly correlated with medication adherence, which was poor. Adherence increased QoL and decreased illness activity.
CONCLUSIONS: Women with more severe disease activity that is, higher DAS-28 scores, increased CRP and ESR, anaemia, and positive anti-CCP antibodies had poorer treatment adherence, according this study. Poor adherence was associated with increased diastolic blood pressure, anaemia, elevated CRP and ESR, and notable anti-CCP positivity in MMAS-4. Our MMAS-4 findings revealed that less adherent individuals had higher rates of deliberate dose skipping and forgetfulness. Many female patients had lower socioeconomic level, according to Kuppuswamy scoring, which was linked to poor adherence and worse WHOQOL-BREF quality of life ratings across all categories. Structural and psychological obstacles must be removed if long-term success and equitable treatment for every patient are to occur. Studies reveal that gender-sensitive, all-encompassing treatment plans addressing clinical and socioeconomic factors of health enhance RA patient adherence and outcomes.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
PCR158
Topic
Economic Evaluation, Methodological & Statistical Research, Patient-Centered Research
Topic Subcategory
Adherence, Persistence, & Compliance
Disease
Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal), No Additional Disease & Conditions/Specialized Treatment Areas