Presentation (CTI)

OBJECTIVES: To systematically evaluate the measurement properties of generic preference-based measures in women with endometriosis.
METHODS: Our systematic review was performed according to the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. Three databases (Pubmed, Embass, and Web of Science) were searched from the database inception to June 18, 2025. Studies were included if they focused on measurement properties of generic preference-based measures in endometriosis patients.
RESULTS: We identified 157 records, of which five studies met the inclusion criteria. The EQ-5D-5L and EQ-5D-3L were evaluated. For construct validity, correlations between EQ-5D-5L and other instruments ranged from 0.02-0.39 with the Female Sexual Function Index, 0.07-0.53 with the Chinese version of the Endometriosis Health Profile-5, and 0.51-0.80 with the Spanish version of the Endometriosis Health Profile-30. The EQ-5D-3L demonstrated moderate correlations (r = 0.32-0.40) with the Turkish version of the Endometriosis Health Profile-30. The EQ-5D-5L showed acceptable known-group validity, discriminating between patients with different symptom severity: pain intensity (effect size = 0.66, p < 0.001), dysmenorrhea (0.48, p < 0.001), and dyspareunia frequency (0.44, p < 0.05). However, it showed limited discrimination across disease classifications and analgesic use (effect size = 0.34). Responsiveness of EQ-5D-5L was supported by large effect sizes over 12 months (0.95).
CONCLUSIONS: Due to the limited included studies, the measurement properties of generic preference-based instruments in endometriosis remain under-explored. Future studies are expected to focus on evaluating a broader spectrum of instruments with higher methodological quality to strengthen evidence for their use in the endometriosis population.