Impact of CIDP on Health-Related Quality of Life Fatigue and Daily Activities: Results From a Real-World International Survey
Author(s)
Febe Marloes Brackx, Ir, MSc1, Clémence Arvin-Berod, PharmD2, Sandra Paci, PhD3, Lucas Van de Veire, MA1, Yasmin Taylor, Mbiol4, Jack Wright, MSc5, Sarah Dewilde, PhD1.
1Services in Health Economics (SHE) BVBA, Schaerbeek, Belgium, 2argenx BV, Ghent, Belgium, 3argenx BV, Zwijnaarde, Belgium, 4Adelphi Real World, Bollington, United Kingdom, 5Adelphi Real World, Bollington, United Kingdom.
1Services in Health Economics (SHE) BVBA, Schaerbeek, Belgium, 2argenx BV, Ghent, Belgium, 3argenx BV, Zwijnaarde, Belgium, 4Adelphi Real World, Bollington, United Kingdom, 5Adelphi Real World, Bollington, United Kingdom.
OBJECTIVES: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an immune-mediated disorder associated with distal and/or proximal weakness and sensory symptoms. Our analysis examines disability, health-related quality of life (HRQoL), fatigue, and limitations in daily activities among CIDP patients, and explores associations between these outcomes.
METHODS: We analyzed matched physician-patient data from Adelphi’s CIDP Disease Specific Programme™, a multinational survey conducted in France, Germany, Italy, and Spain (n=199; April 2022-April 2023). Physicians assessed disability levels using the INCAT score. Patients completed the FACIT-Fatigue scale, the I-RODS scale (assessing limitations in daily activities), and the EQ-5D-5L questionnaire (measuring HRQoL across five domains). We used Spearman rank correlation coefficients and linear regression to estimate associations between INCAT, I-RODS, FACIT-Fatigue and EQ-5D-5L utility values.
RESULTS: Mean (SD) age was 52.37 (12.04) years and 56.8% of patients were male. Patients reported a mean (SD) utility value of 0.65 (0.22); in addition, 67.2% suffered from moderate to severe fatigue, 27.7% experienced substantial limitations in daily activities, and 48.3% had moderate to severe disability.
Utility values demonstrated a moderate negative correlation with INCAT (r = -0.568) and showed strong positive correlations with FACIT and I-RODS (r = 0.799 and r = 0.770, respectively). The EQ-5D-5L’s domains were all negatively associated with FACIT-Fatigue and I-RODS scores, and positively associated with the INCAT score, meaning that greater fatigue, poorer physical functioning, and greater disability were linked to more problems reported across the EQ-5D-5L domains. These associations were strongest for the domains Mobility, Self Care and Usual Activities.
INCAT (beta=-0.024, 95% CI=[-0.036,-0.013]), FACIT-Fatigue (beta=0.009, 95% CI=[0.006,0.012]) and I-RODS (beta=0.004, 95% CI=[0.002,0.005]) were significant covariates in a multiple linear regression model with utility value as outcome.
CONCLUSIONS: Higher disability levels, stronger fatigue and more limitations in daily activities are correlated with lower health-related quality of life in patients with CIDP.
METHODS: We analyzed matched physician-patient data from Adelphi’s CIDP Disease Specific Programme™, a multinational survey conducted in France, Germany, Italy, and Spain (n=199; April 2022-April 2023). Physicians assessed disability levels using the INCAT score. Patients completed the FACIT-Fatigue scale, the I-RODS scale (assessing limitations in daily activities), and the EQ-5D-5L questionnaire (measuring HRQoL across five domains). We used Spearman rank correlation coefficients and linear regression to estimate associations between INCAT, I-RODS, FACIT-Fatigue and EQ-5D-5L utility values.
RESULTS: Mean (SD) age was 52.37 (12.04) years and 56.8% of patients were male. Patients reported a mean (SD) utility value of 0.65 (0.22); in addition, 67.2% suffered from moderate to severe fatigue, 27.7% experienced substantial limitations in daily activities, and 48.3% had moderate to severe disability.
Utility values demonstrated a moderate negative correlation with INCAT (r = -0.568) and showed strong positive correlations with FACIT and I-RODS (r = 0.799 and r = 0.770, respectively). The EQ-5D-5L’s domains were all negatively associated with FACIT-Fatigue and I-RODS scores, and positively associated with the INCAT score, meaning that greater fatigue, poorer physical functioning, and greater disability were linked to more problems reported across the EQ-5D-5L domains. These associations were strongest for the domains Mobility, Self Care and Usual Activities.
INCAT (beta=-0.024, 95% CI=[-0.036,-0.013]), FACIT-Fatigue (beta=0.009, 95% CI=[0.006,0.012]) and I-RODS (beta=0.004, 95% CI=[0.002,0.005]) were significant covariates in a multiple linear regression model with utility value as outcome.
CONCLUSIONS: Higher disability levels, stronger fatigue and more limitations in daily activities are correlated with lower health-related quality of life in patients with CIDP.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
SA51
Topic
Patient-Centered Research, Study Approaches
Topic Subcategory
Surveys & Expert Panels
Disease
Neurological Disorders