Identifying Dogs to Be Screened for Canine Chronic Kidney Disease (cCKD)
Author(s)
ANDREA K. WRIGHT, DVM, MBA, MSc1, Ioulia Chortara, DVM2, George Valiakos, PhD3, Constantina N. Tsokana, PhD4, Irene Chatzipanagiotidou, DVM3, Apostolos Batsidis, PhD5, Polychronis Economou, PhD6, Thaisa L. Sandri, DVM, MSc, PhD1.
1Global Medical Affairs, Zoetis Inc., Parsippany, NJ, USA, 2Asclepius One Health, Athens, Greece, 3Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece, 4School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, 5Department of Mathematics, University of Ioannina, Ioannina, Greece, 6Department of Civil Engineering (Statistics), University of Patras, Patras, Greece.
1Global Medical Affairs, Zoetis Inc., Parsippany, NJ, USA, 2Asclepius One Health, Athens, Greece, 3Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece, 4School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, 5Department of Mathematics, University of Ioannina, Ioannina, Greece, 6Department of Civil Engineering (Statistics), University of Patras, Patras, Greece.
OBJECTIVES: To evaluate eight screening criteria for dogs, combining biomarkers and risk factors for cCKD detection.
METHODS: A multicenter, prospective screening of 1034 dogs aiming to identify the critical factors for the early detection of cCKD. To assess predictive performance dogs were screened for cCKD if they met at least one of the eight criteria (prescribed renal diet, history of acute kidney injury, loss of appetite /weight with prescribed appetite stimulant, elevated creatinine or rise in creatinine and history of Leishmaniosis or Ehrlichiosis). If diagnosed with cCKD, IRIS staging was performed. Statistically significant differences in the independent variables -age, weight, and the presence or absence of diagnostic criteria- were examined between dogs diagnosed with CKD and without CKD. Significance level of alpha = 0.05. was used for non-parametric Mann-Whitney U test continuous variables (age and weight), while Fisher’s exact test was used for the diagnostic criteria. A logistic regression model was constructed with CKD status as the dependent variable and all available independent variables included. Non-significant predictors were removed based on p-values.
RESULTS: Almost 75% of the 283 cCKD cases were detected in early IRIS stage 1 and 2. Increasing age, renal diet, acute kidney injury, loss of appetite /weight, elevated creatinine or rise in creatinine and history of Leishmaniosis or Ehrlichiosis were significant predictors of cCKD.
CONCLUSIONS: By integrating evidence-based criteria into routine examinations, as dogs age or those with specific risk factors like a history of acute kidney injury or relevant infections, the likelihood of detecting cCKD earlier is confirmed.
METHODS: A multicenter, prospective screening of 1034 dogs aiming to identify the critical factors for the early detection of cCKD. To assess predictive performance dogs were screened for cCKD if they met at least one of the eight criteria (prescribed renal diet, history of acute kidney injury, loss of appetite /weight with prescribed appetite stimulant, elevated creatinine or rise in creatinine and history of Leishmaniosis or Ehrlichiosis). If diagnosed with cCKD, IRIS staging was performed. Statistically significant differences in the independent variables -age, weight, and the presence or absence of diagnostic criteria- were examined between dogs diagnosed with CKD and without CKD. Significance level of alpha = 0.05. was used for non-parametric Mann-Whitney U test continuous variables (age and weight), while Fisher’s exact test was used for the diagnostic criteria. A logistic regression model was constructed with CKD status as the dependent variable and all available independent variables included. Non-significant predictors were removed based on p-values.
RESULTS: Almost 75% of the 283 cCKD cases were detected in early IRIS stage 1 and 2. Increasing age, renal diet, acute kidney injury, loss of appetite /weight, elevated creatinine or rise in creatinine and history of Leishmaniosis or Ehrlichiosis were significant predictors of cCKD.
CONCLUSIONS: By integrating evidence-based criteria into routine examinations, as dogs age or those with specific risk factors like a history of acute kidney injury or relevant infections, the likelihood of detecting cCKD earlier is confirmed.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
CO133
Topic
Clinical Outcomes, Epidemiology & Public Health
Topic Subcategory
Clinical Outcomes Assessment
Disease
Veterinary Medicine