Presentation (CTI)

OBJECTIVES: Obesity affects approximately one billion adults worldwide in 2025 and is a major risk factor for numerous diseases, leading to substantial societal costs. Treatment options include lifestyle interventions, bariatric surgery, and pharmacotherapy. Recently, new alternatives, such as incretin-based therapies, have shown promising results but have high acquisition costs. Therefore, it is essential to conduct analyses to evaluate the cost-effectiveness of available treatment strategies and optimize approaches to address obesity.
METHODS: This systematic literature review (SLR) will be conducted and reported according to the Centre for Reviews and Dissemination’s (CRD) guidance and the Preferred Reported Items for Systematic Reviews and Meta-Analysis (PRISMA). Searches will be conducted in MEDLINE, EMBASE and INATHA databases, using title/abstract keywords, subject headings and MeSH terms related to obesity and weight management, lifestyle measures and medical interventions, and cost-effectiveness outcomes. Studies identified in the literature searches will be eligible for inclusion if they report an economic evaluation (e.g., cost-benefit, cost-effectiveness, cost-utility, and cost-minimization analyses) comparing costs and consequences of alternatives in adult people with obesity. A data extraction form and tables will collect and report the characteristics and results of the selected economic evaluation studies.The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement (2022) will be followed to assess the quality of the included studies.
RESULTS: As this is a protocol, no results are available at this stage.
CONCLUSIONS: This SLR will identify, evaluate, and characterize economic evaluations of medical interventions for adult patients living with obesity. We will systematically search relevant databases and apply rigorous inclusion and exclusion criteria to ensure the quality and relevance of the evidence. The review will focus exclusively on comparative studies, providing insights into the relative cost-effectiveness of the available interventions at a global level. Ultimately, this evidence synthesis aims to support decision-making, improve resource allocation, and enhance outcomes for individuals living with obesity.