Global Access Licensing: An Expert Interview Study with Scientists-Inventors and Directors of Technology Transfer Offices Involved in the Development and Commercialization of COVID-19 Vaccines
Author(s)
Shiri Mermelstein, BA, MSc, Hilde Stevens, PhD.
Institute for Interdisciplinary Innovation in Healthcare (I3h), Université Libre de Bruxelles, Brussels, Belgium.
Institute for Interdisciplinary Innovation in Healthcare (I3h), Université Libre de Bruxelles, Brussels, Belgium.
OBJECTIVES: In the early days of the global pandemic, the US Association of University Technology Managers urged universities to adopt time-limited, non-exclusive, and royalty-free licenses to support rapid pandemic response. Although all authorised vaccines involve at least one university-held patent, previous studies found that minimal Intellectual Property (IP) measures were implemented by academic Technology Transfer offices (TTOs) to guarantee universal diffusion of publicly-funded critical health technologies. In this study, we aim to (i) gain insight into how scientists-inventors and TTO directors directly involved in Covid-19 vaccine invention, patenting, and licensing perceive and manage emerging Global Access IP strategies: in pandemics and in peacetime; (ii) map criteria for inclusion of technologies and countries; and (iii) assess the perceived role of conditional governmental and philanthropic funding.
METHODS: We conducted a thematic analysis of semi-structured interviews with a purposively-selected sample of high-profile scientists and TTO directors (n=7 as of June 2025). We distinguish between vaccine Originators (patent-owners) and Developers (institutions developing or testing the final product), and focus on the former. Informants were identified from a small pool, based on published research and the Medicines Patent Pool’s VaxPal database.
RESULTS: Informants were affiliated with top universities in Europe, the UK, and the US (n=5), national research labs (n=1), and public-private partnerships (n=1). Most were male (n=5), heading their own research units; two had established vaccine-focused spin-offs. Valorisation strategies vary widely across EU, UK, and North American public-sector patent-holders, before and during the pandemic. Some European TTOs tend to monetise inventions by quickly selling rather than licensing out their IP rights soon after being granted a patent to either mature spin-offs or incumbents.
CONCLUSIONS: Uptake of IP and access provisions is shaped by short-term commercial decision-making, institutional incentives, and funder conditions. We discuss key effective IP strategies adopted by universities that pertain to ongoing pandemic preparedness debates.
METHODS: We conducted a thematic analysis of semi-structured interviews with a purposively-selected sample of high-profile scientists and TTO directors (n=7 as of June 2025). We distinguish between vaccine Originators (patent-owners) and Developers (institutions developing or testing the final product), and focus on the former. Informants were identified from a small pool, based on published research and the Medicines Patent Pool’s VaxPal database.
RESULTS: Informants were affiliated with top universities in Europe, the UK, and the US (n=5), national research labs (n=1), and public-private partnerships (n=1). Most were male (n=5), heading their own research units; two had established vaccine-focused spin-offs. Valorisation strategies vary widely across EU, UK, and North American public-sector patent-holders, before and during the pandemic. Some European TTOs tend to monetise inventions by quickly selling rather than licensing out their IP rights soon after being granted a patent to either mature spin-offs or incumbents.
CONCLUSIONS: Uptake of IP and access provisions is shaped by short-term commercial decision-making, institutional incentives, and funder conditions. We discuss key effective IP strategies adopted by universities that pertain to ongoing pandemic preparedness debates.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
OP10
Topic
Health Policy & Regulatory, Organizational Practices
Topic Subcategory
Academic & Educational
Disease
Vaccines