Assessing the Clinical and Economic Burden of Surgical Bleeding in Switzerland
Author(s)
Nora Schweizer, PhD1, MELEK Pinar BOSUT, MSc2, Jean-Baptiste Trouiller, PharmD3, Gabrielle Alimorad, BSc, MSc4.
1Johnson & Johnson AG, Zug, Switzerland, 2Johnson & Johnson Medical GmbH, Norderstedt, Germany, 3Johnson & Johnson MedTech, Paris, France, 4Johnson & Johnson MedTech, Markham, ON, Canada.
1Johnson & Johnson AG, Zug, Switzerland, 2Johnson & Johnson Medical GmbH, Norderstedt, Germany, 3Johnson & Johnson MedTech, Paris, France, 4Johnson & Johnson MedTech, Markham, ON, Canada.
OBJECTIVES: Bleeding is a common surgical complication that is associated with substantial clinical and economic burden. However, there is lack of recent robust data estimating the burden of bleeding in Europe. The objective of this study was to compare the healthcare resource utilization (HRU) and costs across a range of surgical procedures in patients with and without surgical bleeding in the Swiss setting.
METHODS: This retrospective observational study utilized the nation-wide inpatient medical and linked cost data provided by the Swiss Federal Statistical Office health services statistics 2017-2022. The procedures of interest included hepatectomy, lung resection, valve procedures, coronary artery bypass grafting (CABG), cholecystectomy, pancreatectomy, gynecological surgeries, and spinal surgeries. The primary objective was to compare the length of stay during index hospitalization for patients with and without surgical bleeding. Secondary endpoints included total inpatient hospital costs and their components, intensive care unit (ICU) admission and duration. Descriptive and multivariable analyses were performed.
RESULTS: The study included 181,232 patients. The overall incidence of surgical bleeding was 11% ranging between 1.4% in lung resection and 64.6% in CABG procedures. After multivariable analysis, patients with surgical bleeding had statistically significant longer mean length of stay (8.4 days vs 3.8 days, p<0.001), higher odds of ICU admission (OR: 14.9, p<0.001), longer average ICU stay (41 days vs 28 days, p<0.001) and higher total inpatient costs (33,631 CHF vs 13,763 CHF, p<0.001) compared with patients without surgical bleeding.
CONCLUSIONS: To our knowledge, this large observational study is the first of its kind in using the Swiss Federal Statistical Office database to report the burden of bleeding. Patients with surgical bleeding had significantly increased HRU and costs compared to those without bleeding. These results highlight the necessity for timely and effective strategies to reduce the risk of bleeding.
METHODS: This retrospective observational study utilized the nation-wide inpatient medical and linked cost data provided by the Swiss Federal Statistical Office health services statistics 2017-2022. The procedures of interest included hepatectomy, lung resection, valve procedures, coronary artery bypass grafting (CABG), cholecystectomy, pancreatectomy, gynecological surgeries, and spinal surgeries. The primary objective was to compare the length of stay during index hospitalization for patients with and without surgical bleeding. Secondary endpoints included total inpatient hospital costs and their components, intensive care unit (ICU) admission and duration. Descriptive and multivariable analyses were performed.
RESULTS: The study included 181,232 patients. The overall incidence of surgical bleeding was 11% ranging between 1.4% in lung resection and 64.6% in CABG procedures. After multivariable analysis, patients with surgical bleeding had statistically significant longer mean length of stay (8.4 days vs 3.8 days, p<0.001), higher odds of ICU admission (OR: 14.9, p<0.001), longer average ICU stay (41 days vs 28 days, p<0.001) and higher total inpatient costs (33,631 CHF vs 13,763 CHF, p<0.001) compared with patients without surgical bleeding.
CONCLUSIONS: To our knowledge, this large observational study is the first of its kind in using the Swiss Federal Statistical Office database to report the burden of bleeding. Patients with surgical bleeding had significantly increased HRU and costs compared to those without bleeding. These results highlight the necessity for timely and effective strategies to reduce the risk of bleeding.
Conference/Value in Health Info
2025-11, ISPOR Europe 2025, Glasgow, Scotland
Value in Health, Volume 28, Issue S2
Code
RWD20
Topic
Clinical Outcomes, Economic Evaluation, Real World Data & Information Systems
Topic Subcategory
Health & Insurance Records Systems
Disease
Surgery