Health-Related Quality of Life in Individuals with Diagnosed Depression, Self-Reported Depression, and Non-Depressed: A Multi-Center Cross-Sectional Study
Author(s)
liu liu1, Yingyao Chen, PhD2, Shimeng Liu, PhD2;
1fudan university, shanghai, shanghai, China, 2Fudan university, Shanghai, China
1fudan university, shanghai, shanghai, China, 2Fudan university, Shanghai, China
Presentation Documents
OBJECTIVES: Depression is a prevalent mental health disorder affecting 280 million people globally and their health-related quality of life (HRQoL). However, differences in HRQoL among individuals with clinically diagnosed depression, self-reported depressive symptoms, and non-depressed individuals remain underexplored. This study aimed to examine health utilities in individuals with diagnosed depression, self-reported depression, and non-depressed individuals and to compare HRQoL among these three groups using the EQ-5D-5L, a widely used instrument for assessing preference-based HRQoL.
METHODS: A multi-center cross-sectional analysis was conducted involving three groups: individuals with diagnosed depression (clinically confirmed by healthcare providers), individuals with self-reported depression (based on SDS scores), and non-depressed individuals (with no significant depressive symptoms). HRQoL was assessed using the EQ-5D-5L, and scores across the five domains were compared among the groups.
RESULTS: A total of 796 participants were included from 25 provinces, municipalities, and autonomous regions across China, of which 350 (43.97%) were patients with clinically diagnosed depression, 210 (26.38%) were individuals with self-reported depression, and 236 (29.65%) were non-depressed individuals. Non-depressed individuals had the highest utility score (mean 0.948, SD 0.097), followed by individuals with clinically diagnosed depression (mean 0.815, SD 0.195), and individuals with self-reported depression had the lowest utility score (mean 0.776, SD 0.230). A significant difference in utility scores was detected among these three groups (P < 0.001), indicating that depressive symptoms harm HRQoL. Compared with non-depressed participants, those with self-reported or clinically diagnosed depression reported more problems across the five core dimensions of the EQ-5D-5L (P < 0.001).
CONCLUSIONS: This study demonstrates that depressive symptoms, whether clinically diagnosed or self-reported, significantly impair health-related quality of life. Additionally, individuals with depression experienced more problems across all five EQ-5D-5L dimensions compared to non-depressed individuals. These findings underscore the importance of early identification and management of depressive symptoms to mitigate their adverse effects on individuals' overall well-being.
METHODS: A multi-center cross-sectional analysis was conducted involving three groups: individuals with diagnosed depression (clinically confirmed by healthcare providers), individuals with self-reported depression (based on SDS scores), and non-depressed individuals (with no significant depressive symptoms). HRQoL was assessed using the EQ-5D-5L, and scores across the five domains were compared among the groups.
RESULTS: A total of 796 participants were included from 25 provinces, municipalities, and autonomous regions across China, of which 350 (43.97%) were patients with clinically diagnosed depression, 210 (26.38%) were individuals with self-reported depression, and 236 (29.65%) were non-depressed individuals. Non-depressed individuals had the highest utility score (mean 0.948, SD 0.097), followed by individuals with clinically diagnosed depression (mean 0.815, SD 0.195), and individuals with self-reported depression had the lowest utility score (mean 0.776, SD 0.230). A significant difference in utility scores was detected among these three groups (P < 0.001), indicating that depressive symptoms harm HRQoL. Compared with non-depressed participants, those with self-reported or clinically diagnosed depression reported more problems across the five core dimensions of the EQ-5D-5L (P < 0.001).
CONCLUSIONS: This study demonstrates that depressive symptoms, whether clinically diagnosed or self-reported, significantly impair health-related quality of life. Additionally, individuals with depression experienced more problems across all five EQ-5D-5L dimensions compared to non-depressed individuals. These findings underscore the importance of early identification and management of depressive symptoms to mitigate their adverse effects on individuals' overall well-being.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
PCR234
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
No Additional Disease & Conditions/Specialized Treatment Areas, SDC: Mental Health (including addition)