Gut Microbiota and Inflammation in Patients Which Schizophrenia
Author(s)
Gaby Lugo1, María Elizabeth Tejero Barrera, MD2, Modesto Goméz López, phD3, Martha Ximena Goméz López, MD3, Carlos Jimenez Zamarripa, MD4;
1MSD, MD, Cdmx, Mexico, 2INMEGEN, Escuela Superior de Medicina, MEXICO, Mexico, 3IPN, Escuela Superior de Medicina, Mexico, Mexico, 4Secreataria de Salud, Hospital Samuel Ramorez Moreno, Mexico, Mexico
1MSD, MD, Cdmx, Mexico, 2INMEGEN, Escuela Superior de Medicina, MEXICO, Mexico, 3IPN, Escuela Superior de Medicina, Mexico, Mexico, 4Secreataria de Salud, Hospital Samuel Ramorez Moreno, Mexico, Mexico
Presentation Documents
OBJECTIVES: Identify the functional diversity of the intestinal microbiota and the inflammatory state in individuals with schizophrenia diagnosed during their first attack of psychosis compared with healthy individuals
METHODS: The intestinal microbiota was characterized by amplifying the genes of the hypervariable regions V6-V8, specifically targeting the genera Bacteroides, Prevotella, and Porphyromonas, as well as the enzyme butyryl-CoA transferase, using RT-PCR. The inflammatory state was assessed by measuring concentrations of interleukins IL-1β, IL-6, IL-10, MCP-1, and TNF-α through MILLIPLEX® luminescence technology (Luminex, USA), which utilizes magnetic beads for the detection of human cytokines and chemokines. Additionally, biochemical parameters, including glucose levels and lipid profiles, were evaluated. All biochemical and genetic analyses were conducted under conditions where no participant was on medication that could influence inflammation or alter the intestinal microbiota
RESULTS: This study included a total of 12 participants (n=12), divided in two groups: 4 individuals diagnosed with schizophrenia; and 8 healthy males as control group. The mean ages were 31.25±8.18 for the schizophrenia group and 23.7 ± 5.67 years for the control group. All participants had normal body mass index according to WHO, and an appropriate percentage body fat for their age. HDL levels were significantly higher in the control group (p = 0.001), while other biochemical parameters were similar between groups.No significant differences were found in the evaluated genes. Additionally, for IL-1β, IL-10, MCP-1 and TNF-α no statistically significant difference were detected. However, showed significant differences, with higher mean concentrations of IL-10 and greater detection frequency in individuals with schizophrenia
CONCLUSIONS: No significant differences were observed in the genes of the V6-V8 hypervariable region, Bacteroides-Prevotella-Porphyromonas, or butyryl-CoA transferase, nor in serum concentrations of IL-1β, MCP-1, and TNF-α. In contrast, elevated levels of IL-6 and IL-10 suggest an inflammatory state in individuals with schizophrenia.
METHODS: The intestinal microbiota was characterized by amplifying the genes of the hypervariable regions V6-V8, specifically targeting the genera Bacteroides, Prevotella, and Porphyromonas, as well as the enzyme butyryl-CoA transferase, using RT-PCR. The inflammatory state was assessed by measuring concentrations of interleukins IL-1β, IL-6, IL-10, MCP-1, and TNF-α through MILLIPLEX® luminescence technology (Luminex, USA), which utilizes magnetic beads for the detection of human cytokines and chemokines. Additionally, biochemical parameters, including glucose levels and lipid profiles, were evaluated. All biochemical and genetic analyses were conducted under conditions where no participant was on medication that could influence inflammation or alter the intestinal microbiota
RESULTS: This study included a total of 12 participants (n=12), divided in two groups: 4 individuals diagnosed with schizophrenia; and 8 healthy males as control group. The mean ages were 31.25±8.18 for the schizophrenia group and 23.7 ± 5.67 years for the control group. All participants had normal body mass index according to WHO, and an appropriate percentage body fat for their age. HDL levels were significantly higher in the control group (p = 0.001), while other biochemical parameters were similar between groups.No significant differences were found in the evaluated genes. Additionally, for IL-1β, IL-10, MCP-1 and TNF-α no statistically significant difference were detected. However, showed significant differences, with higher mean concentrations of IL-10 and greater detection frequency in individuals with schizophrenia
CONCLUSIONS: No significant differences were observed in the genes of the V6-V8 hypervariable region, Bacteroides-Prevotella-Porphyromonas, or butyryl-CoA transferase, nor in serum concentrations of IL-1β, MCP-1, and TNF-α. In contrast, elevated levels of IL-6 and IL-10 suggest an inflammatory state in individuals with schizophrenia.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
CO175
Topic
Clinical Outcomes
Topic Subcategory
Clinical Outcomes Assessment
Disease
No Additional Disease & Conditions/Specialized Treatment Areas, SDC: Mental Health (including addition), STA: Genetic, Regenerative & Curative Therapies