A Retrospective Claims Study Characterizing the Association Between RSV Infection and Acute Otitis Media and Related Burden in Infants and Young Children = 5 years in Japan
Author(s)
Viktor Chirikov, MS, PhD1, Eric A. F. Simoes, MB BS, DCH, MD2;
1OPEN Health, Senior Director, New York, NY, USA, 2University of Colorado School of Medicine, Department of Pediatrics, Aurora, CO, USA
1OPEN Health, Senior Director, New York, NY, USA, 2University of Colorado School of Medicine, Department of Pediatrics, Aurora, CO, USA
Presentation Documents
OBJECTIVES: Respiratory syncytial virus (RSV) emerges as one of the most common viruses associated with acute otitis media (AOM). The primary objective was to characterize the impact of RSV on AOM-related burden in Japan.
METHODS: The Japanese Medical Center Database was used to identify RSV and controls without RSV (02/01/2011- 01/31/2016 followed through 12/31/2017) that were matched and a synthetic index date of RSV diagnosis was assigned among the controls. Four sub-cohorts were created: I) RSV-infected without AOM within 30 days of index (N= 14,639), II) RSV-infected with uncomplicated AOM within 30 days (N= 1,885; 11.1%), III) RSV-infected with complicated AOM within 30 days (N= 498; 2.9%), IV) controls without RSV (N=96,507). Multivariate logistic regression modeled the odds of AOM in the 30 days post-index. AOM-related inpatient and outpatient visits and AOM-associated costs were described over 36 months since index and modeled using multivariate regressions.
RESULTS: Results are reported for cohorts with an index in the first year of life. Among term infants, cohort II (13,773 per 100 children-years; ¥280,780) and cohort III (8,279 per 100 children-years; ¥381,183) had higher cumulative average AOM visits and cost by 36 months of follow-up, compared to cohorts I/IV (both ~2,000-2,500 per 100 children-years; ~¥54,000-69,000). The cost of AOM in the immediate 30 days post-RSV in cohort II (¥53,743) and III (¥45,712) was approximately similar. In adjusted analysis among late preterm and term children, those with RSV had higher odds of AOM 30 days post-index (OR=3.5, p<0.001), compared to controls; prior AOM in the second 6 months of life was the most noteworthy confounder (OR=9.3, p<0.001). In Poisson/Gamma regressions, RSV patients had higher AOM monthly incidence (ratio=1.5, p<0.001) and monthly cost (¥2417 vs ¥1482; ratio=1.6, p<0.001) than controls.
CONCLUSIONS: RSV-associated AOM infection correlated with higher long-term burden of recurrent AOM compared to those without RSV.
METHODS: The Japanese Medical Center Database was used to identify RSV and controls without RSV (02/01/2011- 01/31/2016 followed through 12/31/2017) that were matched and a synthetic index date of RSV diagnosis was assigned among the controls. Four sub-cohorts were created: I) RSV-infected without AOM within 30 days of index (N= 14,639), II) RSV-infected with uncomplicated AOM within 30 days (N= 1,885; 11.1%), III) RSV-infected with complicated AOM within 30 days (N= 498; 2.9%), IV) controls without RSV (N=96,507). Multivariate logistic regression modeled the odds of AOM in the 30 days post-index. AOM-related inpatient and outpatient visits and AOM-associated costs were described over 36 months since index and modeled using multivariate regressions.
RESULTS: Results are reported for cohorts with an index in the first year of life. Among term infants, cohort II (13,773 per 100 children-years; ¥280,780) and cohort III (8,279 per 100 children-years; ¥381,183) had higher cumulative average AOM visits and cost by 36 months of follow-up, compared to cohorts I/IV (both ~2,000-2,500 per 100 children-years; ~¥54,000-69,000). The cost of AOM in the immediate 30 days post-RSV in cohort II (¥53,743) and III (¥45,712) was approximately similar. In adjusted analysis among late preterm and term children, those with RSV had higher odds of AOM 30 days post-index (OR=3.5, p<0.001), compared to controls; prior AOM in the second 6 months of life was the most noteworthy confounder (OR=9.3, p<0.001). In Poisson/Gamma regressions, RSV patients had higher AOM monthly incidence (ratio=1.5, p<0.001) and monthly cost (¥2417 vs ¥1482; ratio=1.6, p<0.001) than controls.
CONCLUSIONS: RSV-associated AOM infection correlated with higher long-term burden of recurrent AOM compared to those without RSV.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
EPH189
Topic
Epidemiology & Public Health
Disease
STA: Vaccines