Estimated Impact of Pre-Exposure Prophylaxis for COVID-19 on Quality of Life and Physical Distancing Among Immunocompromised Individuals and Caregivers
Author(s)
Rebekah Hall, PhD1, Elina Matter, BA, MASc2, Jacqui Bernarde, MSc2, Thomas Strong, MSc3, Michael Watt, PhD4, Silje Akerjord, MSc3, Andrew Lloyd, DPhil2, Katy Gallop, MSc2;
1Acaster Lloyd Consulting Ltd., Research Manager, London, United Kingdom, 2Acaster Lloyd Consulting Ltd., London, United Kingdom, 3AstraZeneca UK, Market Access, London, United Kingdom, 4AstraZeneca UK, Medical and Scientific Affairs, London, United Kingdom
1Acaster Lloyd Consulting Ltd., Research Manager, London, United Kingdom, 2Acaster Lloyd Consulting Ltd., London, United Kingdom, 3AstraZeneca UK, Market Access, London, United Kingdom, 4AstraZeneca UK, Medical and Scientific Affairs, London, United Kingdom
OBJECTIVES: Immunocompromised (IC) individuals may receive insufficient protection from COVID-19 vaccines and potentially require additional interventions to reduce the risk of severe COVID-19. This vignette study estimated the potential impact of pre-exposure prophylaxis (PrEP) for COVID-19 on health-related quality of life (HRQoL) and physical distancing (PD) behaviours among IC individuals and their caregivers.
METHODS: Between April-July 2024, 196 individuals with a self-reported diagnosis of an IC condition classified by the UK Department of Health and Social Care as causing a known/anticipated failure to vaccination (Group A) or sub-optimal vaccination response (Group B), and 48 caregivers (i.e. closest household contact or main contact of care/emotional support for an IC individual) described their own current HRQoL using the EQ-5D-5L and PD behaviour using a COVID-specific questionnaire (PDS-C19©). Participants completed the instruments again whilst considering a vignette describing receipt of PrEP by the IC individual. Differences in responses were calculated to estimate post-PrEP changes.
RESULTS: Overall, IC individuals and caregivers reported current PD behaviour; and stated that PrEP could reduce this and improve their HRQoL. Average difference in EQ-5D-5L score between current HRQoL and the post-PrEP vignette was 0.05 (SD=0.09, p<0.001) for IC individuals and 0.08 (SD=0.11, p<0.001) for caregivers. Largest expected improvements were observed in the usual activities and anxiety/depression domains. Overall, 39% (76/196) of IC individuals and 48% (23/48) of caregivers anticipated moving to a lower intensity category of PD post-PrEP. Group A caregivers anticipated greater reductions in their PD than Group B caregivers. No differences in expected benefits between Group A and Group B IC individuals were observed.
CONCLUSIONS: The findings demonstrate the potential for PrEP to significantly improve HRQoL and reduce the burden of physical distancing among IC individuals and their caregivers. Such impacts should be considered when evaluating the HRQoL benefits of COVID-19 interventions for IC individuals.
METHODS: Between April-July 2024, 196 individuals with a self-reported diagnosis of an IC condition classified by the UK Department of Health and Social Care as causing a known/anticipated failure to vaccination (Group A) or sub-optimal vaccination response (Group B), and 48 caregivers (i.e. closest household contact or main contact of care/emotional support for an IC individual) described their own current HRQoL using the EQ-5D-5L and PD behaviour using a COVID-specific questionnaire (PDS-C19©). Participants completed the instruments again whilst considering a vignette describing receipt of PrEP by the IC individual. Differences in responses were calculated to estimate post-PrEP changes.
RESULTS: Overall, IC individuals and caregivers reported current PD behaviour; and stated that PrEP could reduce this and improve their HRQoL. Average difference in EQ-5D-5L score between current HRQoL and the post-PrEP vignette was 0.05 (SD=0.09, p<0.001) for IC individuals and 0.08 (SD=0.11, p<0.001) for caregivers. Largest expected improvements were observed in the usual activities and anxiety/depression domains. Overall, 39% (76/196) of IC individuals and 48% (23/48) of caregivers anticipated moving to a lower intensity category of PD post-PrEP. Group A caregivers anticipated greater reductions in their PD than Group B caregivers. No differences in expected benefits between Group A and Group B IC individuals were observed.
CONCLUSIONS: The findings demonstrate the potential for PrEP to significantly improve HRQoL and reduce the burden of physical distancing among IC individuals and their caregivers. Such impacts should be considered when evaluating the HRQoL benefits of COVID-19 interventions for IC individuals.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
PCR157
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities, Patient-reported Outcomes & Quality of Life Outcomes
Disease
SDC: Infectious Disease (non-vaccine), STA: Multiple/Other Specialized Treatments