An Interim Analysis of the Burden of Influenza Infection on Health-Related Quality of Life and Work Productivity Among Adults in the United States
Author(s)
Tianyan Hu, Ph.D.1, Alon Yehoshua, Ph.D.1, Joseph C. Cappelleri, MPH, MS, PhD1, Meghan Gavaghan, MPH1, Manuela Di Fusco, Ph.D.1, Xiaowu Sun, PhD2.
1Pfizer Inc., New York, NY, USA, 2Director Biostatistics, CVS Health, Woonsocket, RI, USA.
1Pfizer Inc., New York, NY, USA, 2Director Biostatistics, CVS Health, Woonsocket, RI, USA.
Presentation Documents
OBJECTIVES: This study evaluated Health-Related Quality of Life (HRQoL) and Work Productivity and Impairment (WPAI) among outpatient symptomatic adults with test-confirmed influenza infections in the US in the 2024/25 respiratory season.
METHODS: Adults testing positive for influenza at CVS Health sites and exhibiting ≥1 acute symptom were enrolled between 10/24/2024-1/3/2025 (CT.gov: NCT05160636). Upon enrollment at Day 1, questionnaires on socio-demographics, clinical characteristics, and vaccination status were administered to participants via an online survey platform. Self-reported HRQoL and WPAI outcomes were assessed using validated instruments (EQ-5D-5L, WPAI-GH) at enrollment (Day 1) and being recalled for the pre-infection baseline. Outcomes were summarized using descriptive statistics for each time point and compared between Day 1 and pre-infection baseline using paired t-tests.
RESULTS: One hundred and twenty-four influenza participants were included in the interim analysis. Mean (SD) age was 41.6 years (12.4), 75.8% were female, 42.7% at least one comorbidity, and 105 (84.7%) were employed at enrollment. The mean (SD) of EQ-Visual Analogue Scale (EQ-VAS) scores and Utility Index (UI) were 88.6 (11.3) and 0.95 (0.08), respectively, for the pre-infection baseline. They dropped to 59.7 (19.6) and 0.77 (0.17), respectively at enrollment following infection. The changes were statistically significant with mean changes of -28.9 (P<0.001) in EQ-VAS and -0.17 (P<0.001) in UI scores. Relative to baseline, the mean work productivity time loss at enrollment was 76.9% (P<0.001), the mean change in absenteeism was 50.9% (P<0.001), and the mean change in activity impairment was 64.9% (P<0.001).
CONCLUSIONS: Influenza infections are associated with a negative impact on health-related quality of life and work productivity among US adults during the 2024/2025 season. These findings highlight the broad consequences of influenza infections and help recognize the value of preventive approaches such as influenza vaccination.
METHODS: Adults testing positive for influenza at CVS Health sites and exhibiting ≥1 acute symptom were enrolled between 10/24/2024-1/3/2025 (CT.gov: NCT05160636). Upon enrollment at Day 1, questionnaires on socio-demographics, clinical characteristics, and vaccination status were administered to participants via an online survey platform. Self-reported HRQoL and WPAI outcomes were assessed using validated instruments (EQ-5D-5L, WPAI-GH) at enrollment (Day 1) and being recalled for the pre-infection baseline. Outcomes were summarized using descriptive statistics for each time point and compared between Day 1 and pre-infection baseline using paired t-tests.
RESULTS: One hundred and twenty-four influenza participants were included in the interim analysis. Mean (SD) age was 41.6 years (12.4), 75.8% were female, 42.7% at least one comorbidity, and 105 (84.7%) were employed at enrollment. The mean (SD) of EQ-Visual Analogue Scale (EQ-VAS) scores and Utility Index (UI) were 88.6 (11.3) and 0.95 (0.08), respectively, for the pre-infection baseline. They dropped to 59.7 (19.6) and 0.77 (0.17), respectively at enrollment following infection. The changes were statistically significant with mean changes of -28.9 (P<0.001) in EQ-VAS and -0.17 (P<0.001) in UI scores. Relative to baseline, the mean work productivity time loss at enrollment was 76.9% (P<0.001), the mean change in absenteeism was 50.9% (P<0.001), and the mean change in activity impairment was 64.9% (P<0.001).
CONCLUSIONS: Influenza infections are associated with a negative impact on health-related quality of life and work productivity among US adults during the 2024/2025 season. These findings highlight the broad consequences of influenza infections and help recognize the value of preventive approaches such as influenza vaccination.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
PCR202
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
SDC: Infectious Disease (non-vaccine)