Economic Burden of Non-Pharmacological Treatment in Amyotrophic Lateral Sclerosis in Brazil's Public Healthcare System: A 2022 Real World Cost Analysis

Author(s)

Matheus Costa e Silva, BSc, Júlio Henri Silva, BSc, Letícia Guimarães, BSc, Ana Luiza Guerra, BSc, Caio de Marchi Huerta, BSc, Gisele Lemes Veiga Araujo, MSc, Carolina Guilhon, BSc, Leandro Santos, BSc.
Daiichi Sankyo, São Paulo, Brazil.

Presentation Documents

OBJECTIVES: This study, based on the Clinical Protocol and Therapeutic Guidelines(PCDT) for Amyotrophic Lateral Sclerosis(ALS) in Brazil’s Public Healthcare System(SUS), which offers only one therapeutic option(Riluzole), aims to evaluate the average cost and frequency of non-pharmacological treatment options for ALS patients using SUS public data in 2022.
METHODS: A descriptive cost analysis for non-pharmacological therapeutic options was conducted using SUS public data. Outpatient data were colected through Individualized Outpatient Production Form database. The study identified ALS cases using ICD-10 G12.2 attended during 2022. Costs were updated for inflation through October 2024 using the Broad National Consumer Price Index(IPCA).
RESULTS: There were 5,894 patients identified with ALS. The analysis of clinical procedures as non-pharmacological treatment options describes a total of 97,934 events, incurring a cost of R$814,236.94. Representing an average cost of R$8.31 and a frequency of 16.6 procedures per person per year. The highest costs were associated with physiotherapy, totaling R$525,498.13 for 66,428 sessions, with an average cost of R$7.90. In contrast, orthoses, prostheses, and special materials, though less frequent with 920 events, accounted for a substantial cost of R$401,112.38. The average cost per item is R$435.99, with a frequency of 0.2 per person per year. The standard wheelchair had 300 occurrences with an average cost of R$572, achieving the highest cost among this therapeutic option.
CONCLUSIONS: The data highlights the critical role of clinical procedures in ALS care, given their high frequency and cumulative cost, while orthoses, prostheses, and special materials, though less frequent, impact costs due to their high individual expense. Efficient resource allocation and cost management within SUS are essential for sustainable care.

Conference/Value in Health Info

2025-05, ISPOR 2025, Montréal, Quebec, CA

Value in Health, Volume 28, Issue S1

Code

HPR86

Topic

Health Policy & Regulatory

Topic Subcategory

Public Spending & National Health Expenditures

Disease

SDC: Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal), SDC: Neurological Disorders, SDC: Rare & Orphan Diseases

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