Relationship between Genetic Polymorphisms and Clinical Parameters in Mexican Postmenopausal Women: A Study on Cardiovascular Health
Author(s)
Gaby Lugo, Msc1, Juan Castillo Cruz, phD2, María Esther Ocharan- Hernandez, phD2, Carlos Jimenez Zamarripa, Msc3, Claudia Calzada, phD2;
1Instituto Politecnico Nacional, Escuela Superior de Medicina, Ciudad de México, Mexico, 2Instituto Politecnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación, Ciudad de México, Mexico, 3Secretaria de Salud, Hospital Psiquiatrico, Mexico
1Instituto Politecnico Nacional, Escuela Superior de Medicina, Ciudad de México, Mexico, 2Instituto Politecnico Nacional, Escuela Superior de Medicina, Sección de Estudios de Posgrado e Investigación, Ciudad de México, Mexico, 3Secretaria de Salud, Hospital Psiquiatrico, Mexico
Presentation Documents
OBJECTIVES: To evaluate the biochemical parameters and genetic polymorphisms associated with cardiovascular health in overweight postmenopausal women.
METHODS: A clinical, observational, longitudinal, prospective study was conducted among women aged 45 to 55 years, classified as normotensive or hypertensive based on clinical history. Biochemical parameters, including estradiol, total cholesterol, HDL, LDL, triglycerides, and nitric oxide levels, were measured. Genetic polymorphisms (ACE I/D, angiotensinogen M235T, and XbaI at the estrogen receptor alpha) were identified using RT-PCR with specific oligonucleotide sequences.
RESULTS: A total of 87 Mexican postmenopausal women participated, comprising 60 normotensive and 27 hypertensive individuals. The mean arterial systolic blood pressure was 116.7 mmHg (95%CI: 114.54-118.99), and the majority were classified as overweight (mean BMI: 28.7, 95%CI: 27.95-29.60). HDL levels were borderline, with 50% exhibiting values indicating increased cardiovascular risk. BMI correlated significantly with body fat, waist-to-height ratio and adiposity index, r=0.54, r=0.55 and r=0.84, respectively; triglycerides maintain an inversely proportional relationship with LDL (r=-0.27); and atherogenic index correlated positively with the Heard scale r=0.46. In normotensive women, the main ACE I/D polymorphism was I/D (63.3%); while hypertensive women was D/D(55.6%). The XbaI variant was common in normotensive women (xX, 76.1%) and hypertensive women (xx, 42.3%). The angiotensinogen M235T variant was prevalent in normotensive women (80.5%) and reduced hypertension risk by 25%.
CONCLUSIONS: This study indicates that genetic polymorphisms and obesity metrics are associated with cardiovascular health in postmenopausal women, emphasizing the importance of integrating biochemical parameters and genetic predispositions in cardiovascular risk assessment.
METHODS: A clinical, observational, longitudinal, prospective study was conducted among women aged 45 to 55 years, classified as normotensive or hypertensive based on clinical history. Biochemical parameters, including estradiol, total cholesterol, HDL, LDL, triglycerides, and nitric oxide levels, were measured. Genetic polymorphisms (ACE I/D, angiotensinogen M235T, and XbaI at the estrogen receptor alpha) were identified using RT-PCR with specific oligonucleotide sequences.
RESULTS: A total of 87 Mexican postmenopausal women participated, comprising 60 normotensive and 27 hypertensive individuals. The mean arterial systolic blood pressure was 116.7 mmHg (95%CI: 114.54-118.99), and the majority were classified as overweight (mean BMI: 28.7, 95%CI: 27.95-29.60). HDL levels were borderline, with 50% exhibiting values indicating increased cardiovascular risk. BMI correlated significantly with body fat, waist-to-height ratio and adiposity index, r=0.54, r=0.55 and r=0.84, respectively; triglycerides maintain an inversely proportional relationship with LDL (r=-0.27); and atherogenic index correlated positively with the Heard scale r=0.46. In normotensive women, the main ACE I/D polymorphism was I/D (63.3%); while hypertensive women was D/D(55.6%). The XbaI variant was common in normotensive women (xX, 76.1%) and hypertensive women (xx, 42.3%). The angiotensinogen M235T variant was prevalent in normotensive women (80.5%) and reduced hypertension risk by 25%.
CONCLUSIONS: This study indicates that genetic polymorphisms and obesity metrics are associated with cardiovascular health in postmenopausal women, emphasizing the importance of integrating biochemical parameters and genetic predispositions in cardiovascular risk assessment.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
CO60
Topic
Clinical Outcomes
Disease
STA: Genetic, Regenerative & Curative Therapies, STA: Personalized & Precision Medicine