Presentation (CTI)

OBJECTIVES: The Health Utilities Index Mark 2 (HUI2, 6 items excluding fertility) and Mark 3 (HUI3, 8 items) as well as the Patient-Reported Outcomes Measurement Information System (PROMIS®) preference score (PROPr) are commonly used preference-based measures. This study employs mapping approaches to align the PROPr and the PROMIS domains included in the PROPr, plus Anxiety, with HUI preference scores in the US.
METHODS: A sample of 983 adults completed an online survey administered by ICF and SurveyNow in 2016. Ordinary least-squares regression with equipercentile correction was used to map HUI preference scores onto PROMIS domains and PROPr preference scores based on this general population sample.
RESULTS: The mean age of respondents was 50 years, with 54% identifying as female, 16% as Hispanic, and 77% as White. HUI2 preference scores were explained by the PROMIS domains of Depression, Pain, Sleep, and Physical Function, as well as by the PROPr preference scores. HUI3 preference scores were explained by the PROMIS domains of Cognitive Function, Depression, Pain, Physical Function, Sleep, and Social Roles, as well as by the PROPr preference scores. Small differences and moderate-to-high agreement were observed between the actual and predicted HUI2 or HUI3 preference scores for both mapping models.
CONCLUSIONS: HUI2 and HUI3 preference scores can be estimated from PROMIS health domains and the PROPr. The results indicate that while HUI2 and PROPr share some content, PROPr provides additional information on Fatigue, Social Roles, and Cognitive Function. Similarly, although HUI3 and PROPr largely overlap in content domains, PROPr offers additional insights into Fatigue.