Health utilities of patients with multidrug-resistant tuberculosis and its influencing factors: A cross-sectional study based on EQ-5D-5L in China
Author(s)
Yu Chen, Master1, Handong Chen, Master1, Zhihao Zhao, Bachelor1, Jingyi Wang, Bachelor1, Qing Lin, Bachelor2, Yan Li, Bachelor2, Ming Hu, PhD1;
1West China School of Pharmacy, Sichuan University, Chengdu, China, 2Chengdu Public Health Clinical Medical Center, Chengdu, China
1West China School of Pharmacy, Sichuan University, Chengdu, China, 2Chengdu Public Health Clinical Medical Center, Chengdu, China
Presentation Documents
OBJECTIVES: Multidrug-resistant tuberculosis (MDR-TB) affects the health-related quality of life (HRQoL) of patients, this study aims to provide health utility values (HUVs) for MDR-TB patients in China and to identify the factors influencing HUVs.
METHODS: A cross-sectional survey (Ethics Approval and Register No. K2022017) was conducted in a designated tuberculosis medical institution in Sichuan Province in 2024. MDR-TB patients identified by their registration number who attended in the institution between 2021 to 2023 were invited to complete a questionnaire. The socio-demographic characteristics, lifestyle, treatment status were collected and HUVs got by EQ-5D-5L were calculated. Univariate and multivariate analyses were used to assess the factors influencing HUVs.
RESULTS: A total of 195 participants were finally included from 537 eligible patients after excluding invalid questionnaires. The mean age was 34.85±11.99 years, with male being 60.0%. Of these patients, 98 were undergoing treatment and 97 had finished treatment. The most frequently reported difficulty were ‘pain/discomfort’ (56.92%) and ‘anxiety/depression’ (52.82%). The mean HUV and EQ visual analogue scale (VAS) score of all patients were 0.857±0.182 and 75.79±17.42, respectively. And the HUV was 0.893±0.157 in patients who had completed treatment, which was higher than that of 0.822±0.198 in patients undergoing treatment (p<0.001). The univariate analysis showed that age, occupation, labor intensity, treatment status, treatment effects, adverse reactions, medication and perceived discrimination were the main factors affecting HUV. The multivariate analysis further suggested that patients with unemployment, depression and anxiety, feelings of discrimination, and patients need for family care when taking medication were statistically significantly related to lower HUVs.
CONCLUSIONS: The study provided the HUVs of MDR-TB patients in China which is a lack of evidence for the economic evaluation of interventions. The identified factors could also contribute to healthcare management and improving the HRQoL for MDR-TB patients.
METHODS: A cross-sectional survey (Ethics Approval and Register No. K2022017) was conducted in a designated tuberculosis medical institution in Sichuan Province in 2024. MDR-TB patients identified by their registration number who attended in the institution between 2021 to 2023 were invited to complete a questionnaire. The socio-demographic characteristics, lifestyle, treatment status were collected and HUVs got by EQ-5D-5L were calculated. Univariate and multivariate analyses were used to assess the factors influencing HUVs.
RESULTS: A total of 195 participants were finally included from 537 eligible patients after excluding invalid questionnaires. The mean age was 34.85±11.99 years, with male being 60.0%. Of these patients, 98 were undergoing treatment and 97 had finished treatment. The most frequently reported difficulty were ‘pain/discomfort’ (56.92%) and ‘anxiety/depression’ (52.82%). The mean HUV and EQ visual analogue scale (VAS) score of all patients were 0.857±0.182 and 75.79±17.42, respectively. And the HUV was 0.893±0.157 in patients who had completed treatment, which was higher than that of 0.822±0.198 in patients undergoing treatment (p<0.001). The univariate analysis showed that age, occupation, labor intensity, treatment status, treatment effects, adverse reactions, medication and perceived discrimination were the main factors affecting HUV. The multivariate analysis further suggested that patients with unemployment, depression and anxiety, feelings of discrimination, and patients need for family care when taking medication were statistically significantly related to lower HUVs.
CONCLUSIONS: The study provided the HUVs of MDR-TB patients in China which is a lack of evidence for the economic evaluation of interventions. The identified factors could also contribute to healthcare management and improving the HRQoL for MDR-TB patients.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
PCR86
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities, Patient-reported Outcomes & Quality of Life Outcomes
Disease
No Additional Disease & Conditions/Specialized Treatment Areas, SDC: Infectious Disease (non-vaccine)