Evaluating the National and Regional Prevalence and Incidence Rates of Hepatitis Delta Virus Among Patients With Hepatitis B Virus Infection in Italy
Author(s)
Pietro Lampertico, MD, PhD1, Valentina Perrone, M.Pharm.2, Luca Degli Esposti, PhD2, Melania Leogrande, M.Sc.2, Chong H Kim, MPH, MS, PhD3, Marvin Rock, PhD3;
1University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy, 2Clicon Srl Società Benefit, Health, Economics & Outcomes Research, Bologna, Italy, 3Gilead Sciences, Inc., HEOR—Global Value & Access, Foster City, CA, USA
1University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy, 2Clicon Srl Società Benefit, Health, Economics & Outcomes Research, Bologna, Italy, 3Gilead Sciences, Inc., HEOR—Global Value & Access, Foster City, CA, USA
Presentation Documents
OBJECTIVES: Hepatitis delta virus (HDV) is the most severe form of viral hepatitis and affects nearly 5% of people living with chronic hepatitis B virus monoinfection (HBV only). This retrospective study evaluated national and regional prevalence and incidence of HDV among people with HBV in Italy.
METHODS: Administrative databases from local health units, covering 12 million people, were screened for patients with ≥1 inpatient or outpatient claim (using ICD-9-CM or exemption codes, respectively) between 01/01/2009 and 30/06/2022 (study period). Patients aged ≥18 years with an HDV or HBV only diagnosis between 01/01/2010 and 31/12/2021 (identification period), no prior HDV diagnosis, and who were alive as of 31/12/2021 were identified. The index date was defined as the date of a patient’s first claim.
RESULTS: Among 16,526 Italian patients, 11,266 were included (HDV, n = 754; HBV only, n = 10,512). Nationally, HDV prevalence was 6.7% (range, 6.3%-7.1%) during the study period, which was higher in the outpatient vs inpatient populations (10.3% vs 6.0%). In the northern, central, and southern regions, HDV prevalence was 4.5%, 5.2%, and 8.6%, respectively. Moreover, HDV prevalence was higher in the southern region for both outpatient (north, 3.9%; central, 3.9%; south, 12.9%) and inpatient (north, 4.6%; central, 5.4%; south, 7.4%) populations. National HDV incidence was 5.9% (range, 0.3%-5.3%) and was higher in the outpatient (9.1%) vs inpatient population (5.4%). The national HDV incidence rate declined from 5.3% in 2010 to 0.3% in 2021.
CONCLUSIONS: The overall national prevalence and incidence of HDV in Italy were 6.7% and 5.9%, respectively, between 2010 and 2021. HDV prevalence was higher in the southern region of Italy compared with the northern and central regions, and was higher in outpatient vs inpatient populations. These data highlight the importance of addressing both national and regional needs for early screening, diagnosis, and treatment of HDV.
METHODS: Administrative databases from local health units, covering 12 million people, were screened for patients with ≥1 inpatient or outpatient claim (using ICD-9-CM or exemption codes, respectively) between 01/01/2009 and 30/06/2022 (study period). Patients aged ≥18 years with an HDV or HBV only diagnosis between 01/01/2010 and 31/12/2021 (identification period), no prior HDV diagnosis, and who were alive as of 31/12/2021 were identified. The index date was defined as the date of a patient’s first claim.
RESULTS: Among 16,526 Italian patients, 11,266 were included (HDV, n = 754; HBV only, n = 10,512). Nationally, HDV prevalence was 6.7% (range, 6.3%-7.1%) during the study period, which was higher in the outpatient vs inpatient populations (10.3% vs 6.0%). In the northern, central, and southern regions, HDV prevalence was 4.5%, 5.2%, and 8.6%, respectively. Moreover, HDV prevalence was higher in the southern region for both outpatient (north, 3.9%; central, 3.9%; south, 12.9%) and inpatient (north, 4.6%; central, 5.4%; south, 7.4%) populations. National HDV incidence was 5.9% (range, 0.3%-5.3%) and was higher in the outpatient (9.1%) vs inpatient population (5.4%). The national HDV incidence rate declined from 5.3% in 2010 to 0.3% in 2021.
CONCLUSIONS: The overall national prevalence and incidence of HDV in Italy were 6.7% and 5.9%, respectively, between 2010 and 2021. HDV prevalence was higher in the southern region of Italy compared with the northern and central regions, and was higher in outpatient vs inpatient populations. These data highlight the importance of addressing both national and regional needs for early screening, diagnosis, and treatment of HDV.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
EPH45
Topic
Epidemiology & Public Health
Disease
SDC: Infectious Disease (non-vaccine)