Presentation (CTI)

OBJECTIVES: To estimate the economic burden of Chronic Kidney Disease (CKD) in Type 2 Diabetes (T2D), considering the standard of care and the costs of cardiovascular events in Colombia
METHODS: From a social perspective, direct healthcare system (management of CKD and T2D considering hospitalization for cardiovascular events) and household costs were evaluated, also indirect costs using Disability-Adjusted Life Years (DALY) and average income per worker. Direct costs per patient/year were calculated using a macro-costing approach. Hospitalization costs for cardiovascular risk were weighted with the following probabilities (calculated using KDIGO 2024): (a) 24,84% for microalbuminuria, 42,1% for macroalbuminuria, and 94,67% for end-stage renal disease (ESRD) in hospitalization for heart failure (b) 33,71% for microalbuminuria, 44,56% for macroalbuminuria, and 59,08% for ESRD in non-fatal myocardial infarction and (c) 31,93% for microalbuminuria, 39,01% for macroalbuminuria, and 55,33% for ESRD in non-fatal stroke. These values were used to conduct a cost and DALYs simulation associated with disease progression using a Markov model, employing a transition matrix for a cohort of 1.000 patients aged 40 with T2D
RESULTS: Using an exchange rate of COP$4.061 Colombian pesos per US dollar (USD), total direct cost in 2024 US dollars per patient/year was: USD$2.133 for microalbuminuria, USD$3.300 for macroalbuminuria and USD$13.879 for ESRD. Total healthcare costs per patient/year were USD$2.100 for microalbuminuria, USD$2.848 for macroalbuminuria y USD$10.705 for ESRD, but those related only to cardiovascular hospitalization were USD$1.987 for microalbuminuria, USD$2.735 for macroalbuminuria and USD$4.405 for ESRD. Out-of-pocket expenses were USD$33 for microalbuminuria, USD$452 for macroalbuminuria and USD$3.174 for ESRD per patient/year. Indirect costs were USD$526 for micro and macroalbuminuria, USD$2.888 for ESRD, and USD$5.059 for death stage, with a total of 10,6 DALYs per person
CONCLUSIONS: Economic burden of CKD in T2D associated with hospitalization for cardiovascular risk in Colombia is approximately USD$105.582 per patient in time horizon of 37 years