Sociodemographic Indicators and Quality of Life Impact of Major Depressive Disorder in the United States Using the Medical Expenditure Panel Survey

Author(s)

Chitnis A1, O'Callaghan L2, Fournier AA3, Cloutier M4, Gagnon-Sanschagrin P4, Maitland J4, Bellefleur R4, Greenberg P3
1Biogen Inc., Cambridge, MA, USA, 2Sage Therapeutics, Inc., Cambridge, MA, USA, 3Analysis Group Inc., Boston, MA, USA, 4Analysis Group, Inc., Montreal, QC, Canada

OBJECTIVES: To compare sociodemographic indicators and quality-of-life outcomes between adults with and without major depressive disorder (MDD) in the United States.

METHODS: Adults (≥18 years) were identified from Medical Expenditure Panel Survey (MEPS) data (2015-2019; panels 20-23). Adults with a score of ≥3 on the Patient Health Questionnaire-2 (PHQ-2; self-report) were classified into the MDD cohort; remaining adults were classified into the without MDD cohort. Sociodemographic indicators (household composition, marital status, employment, household poverty, education) and quality-of-life outcomes (12-item short form survey version 2 [SF-12v2] mental component score [MCS] and physical component score [PCS], 6-dimension short form survey [SF-6D] utility score) were compared between cohorts. Results were weighted using MEPS nationally representative person-level weights and adjusted for selected characteristics (e.g., gender, age, race). Raw proportions are presented along with adjusted outcome measures.

RESULTS: Overall, 35,367 adults met sample selection criteria (2,468 with MDD; 32,899 without MDD). Mean age was 47.5 and 47.2 years among adults with and without MDD and 59.7% and 51.6% were female, respectively. Adults with MDD and without MDD differed across multiple sociodemographic indicators. Specifically, adults with MDD were 39% less likely to live with someone else (72.5% vs 81.3%), 51% less likely to be married (36.5% vs 54.0%), 58% less likely to have completed at least a bachelor’s degree (17.9% vs 34.6%), 68% less likely to be employed (42.8% vs 67.6%), and 3.5-times as likely to be living below the poverty line (27.5% vs 9.7%) versus adults without MDD (all p<0.001). Adults with MDD had a 16.6-point, 7.6-point, and 0.2-point lower SF-12v2 MCS and PCS score and SF-6D score, respectively, versus adults without MDD (all p<0.001).

CONCLUSIONS: This real-world study highlights that MDD may be associated with multiple aspects of one’s life, including social networks through household composition and marital status, human capital through education and employment, and overall wellbeing.

Conference/Value in Health Info

2023-05, ISPOR 2023, Boston, MA, USA

Value in Health, Volume 26, Issue 6, S2 (June 2023)

Code

PCR14

Topic

Patient-Centered Research, Study Approaches

Topic Subcategory

Patient-reported Outcomes & Quality of Life Outcomes, Surveys & Expert Panels

Disease

Mental Health (including addition)

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