Public Health Impact of Switching From a Trivalent to a Quadrivalent Inactivated Influenza Vaccine in the Dominican Republic
Author(s)
Zerda I1, Gorecki M1, Clay E2, Brea J3, De Ramon J4, Garcia W5, Botero L5, Londono S5
1Creativ-Ceutical, Krakow, Poland, 2Creativ-Ceutical, Paris, France, 3Dominican Vaccination Society, Santo Domingo, Dominican Republic, 4Instituto Tecnológico de Santo Domingo, Santo Domingo, Dominican Republic, 5Sanofi, Bogota, Colombia
Presentation Documents
OBJECTIVES: In 2006, the Dominican Republic Ministry of Public Health implemented the seasonal influenza vaccination program with the trivalent influenza vaccine (TIV). This study aims to retrospectively estimate the comparative disease burden of influenza during seasons 2010 to 2019 with QIV-SD vaccination, over the actual adopted TIV scenario. METHODS: The number of influenza cases, general practice (GP) visits, hospitalizations, and deaths due to influenza, alongside the costs of treatment and workdays lost were compared in scenarios with TIV and QIV over nine influenza seasons. Public payer and societal perspectives were considered. Influenza incidence and complications rates were extracted from the literature and the Pan American Health Organisation database. The distribution of circulating influenza strains was derived from the PAHO database. Vaccine efficacy and coverage rates were based on clinical trials and national statistics, respectively. Modelling results were validated by local experts. Deterministic sensitivity analysis was explored. RESULTS: The vaccination rate among high-risk groups was relatively low (14% in children aged <2 years, 5% in people aged ≥65 years, 57% among health workers and 16% among pregnant women) and the burden of disease reported was substantial. Each year the disease resulted in an average of 404,251 consultations, 6,728 hospitalizations and 358 deaths. Retrospectively, replacing TIV with QIV would have resulted in avoiding 4,393 influenza cases, 2,742 GP visits, 96 hospitalizations and 4 deaths, reported over the seasons 2010 to 2019. As a result, RD$ 8,416,789 and RD$ 27,656,727 would have been saved from payer and societal perspectives, respectively. Sensitivity analysis confirmed these findings. CONCLUSIONS: Switching from TIV to QIV in the past influenza immunization campaigns in the Dominican Republic would have prevented illnesses and deaths, reducing health care resource use. To achieve a higher effect, the replacement of TIV with QIV should be accompanied by the increase of vaccination coverage rates.
Conference/Value in Health Info
2022-11, ISPOR Europe 2022, Vienna, Austria
Value in Health, Volume 25, Issue 12S (December 2022)
Code
EE247
Topic
Economic Evaluation, Epidemiology & Public Health
Topic Subcategory
Budget Impact Analysis, Public Health
Disease
No Additional Disease & Conditions/Specialized Treatment Areas