Treatment Patterns in Women with Uterine Fibroids and Heavy Menstrual Bleeding: Results from a Large UF Claims Database
Author(s)
McKain L1, Edsall K2, Lickert C1
1Myovant Sciences Inc., Brisbane, CA, USA, 2Charles River Associates, Washington, DC, USA
OBJECTIVES: Uterine Fibroids (UF) are the most common benign pelvic tumors, with >60% of cases diagnosed in women age 30-44 years. Heavy menstrual bleeding (HMB) and pain are the most common symptoms. Clinical guidelines were last updated in 2008 and include limited options for pharmacological therapies and uterine-sparing procedures. The primary objective of this study was to assess current treatment patterns in women diagnosed with both UF and HMB. METHODS: Using administrative claims data from the IQVIA Pharmetrics database (1/1/2010 -12/31/2019), incident women with UF and HMB were identified. The index date was defined as the date of the first claim for UF. Women aged 18-50 years old, with no UF diagnosis during the 12 months pre-index date, > 2 years of follow-up and >2 HMB claims were included. Treatment patterns over the first 12 months post-index were assessed in terms of pharmacologic therapies and procedures, including hysterectomy. RESULTS: The study included 66,313 women diagnosed with UF and HMB; their mean age was 42.6 years (SD: 5.4). HMB diagnosis preceded the UF diagnosis in 56.5% of cases, 21.7% of patients had first a claim for UF, while 21.8% had claim(s) for both on the same day. Within 12-month post-index, 54.7% of the patients had no pharmacological therapy, 55.1% underwent a gynecological procedure, hysterectomy being the most frequent (30.9%). Of patients with a hysterectomy, majority (83%) were < 45 years old, 31% < 35years old and 66% had no pharmacological therapy prescribed between the index date and procedure date. CONCLUSIONS: The majority of symptomatic women diagnosed with UF and HMB did not receive pharmacological therapy within one year of diagnosis and follow-up. Hysterectomy was the most common procedure. There is a need to better understand why symptomatic women fail to receive pharmacological treatment and why a hysterectomy is the initial intervention.
Conference/Value in Health Info
2020-11, ISPOR Europe 2020, Milan, Italy
Value in Health, Volume 23, Issue S2 (December 2020)
Code
PIH40
Topic
Epidemiology & Public Health, Health Service Delivery & Process of Care, Real World Data & Information Systems
Topic Subcategory
Disease Classification & Coding, Health & Insurance Records Systems, Treatment Patterns and Guidelines
Disease
Reproductive and Sexual Health