OBJECTIVES: To describe self-reported health related quality of life (HRQL) from general population of Argentina, Brazil, Chile and Uruguay and to report population norms based on EQ-5D. METHODS: We included data from the 2009 national health risk survey in Argentina (n=41,392) and from the participants of the EQ-5D valuation studies Brazil (n=3,362, Viegas Andrade 2013), Chile (n=2000, Zárate 2011) and Uruguay (n=792). We estimated mean VAS values and EQ-5D index by age, gender and the presence of limitations in any of the EQ-5D domains. We also explored the most frequent health states (those which include at least 90% of the population).  RESULTS: Self-rated mean VAS was 76.5 (IC95% 76.2-76.8), 83.8 (83.3- 84.3), 75.7 (74.8-76.6) and 79.8 (78.6-80.9) in Argentina, Brazil, Chile and Uruguay respectively.  The percentage of individuals without limitations was 60.9%, 44.3%, 49.8%, and 44.6% in Argentina, Brazil, Chile and Uruguay respectively.  The EQ-5D TTO-based index values showed slightly higher values in Argentina and Uruguay (0.910; CI95% 0.907-0.913 and 0.957; CI95% 0.951-0.962) than in Brazil and Chile (0.892, CI95% 0.888-0.897 and 0.80, CI95% 0.79-0.81). In all countries, both VAS and EQ-5D index values decreased with increasing age, and were lower in females. Out of the 243 possible EQ-5D-3L health states only eight were present in at least 90% of the population in Argentina, nine in Brazil, and 19 in Chile. In Uruguay, only 33 out of the possible 3125 EQ-5D-5L health states were referred at least by 90% of the participants. In general, the prevalent states were the ones with mild limitations in pain-discomfort, anxiety-depression or mobility.  CONCLUSIONS: This is the first collaborative work between Latin-American EQ-5D researchers from four countries. This study summarizes population norms for the region that can be used in decision-making as well as in research